November 25, 2009

Hanna E. Silber, Nicolas Frey, and Mats O. Karlsson

An Integrated Glucose-Insulin Model to Describe Oral Glucose Tolerance Test Data in Healthy Volunteers
J Clin Pharmacol first published on November 25, 2009 as doi:10.1177/0091270009341185 [Abstract] [PDF]  

Zhenhua Xu, Qingmin Wang, Yanli Zhuang, Bart Frederick, Hong Yan, Esther Bouman-Thio, Joseph C. Marini, Monica Keen, David Snead, Hugh M. Davis, and Honghui Zhou

Subcutaneous Bioavailability of Golimumab at 3 Different Injection Sites in Healthy Subjects
J Clin Pharmacol first published on November 25, 2009 as doi:10.1177/0091270009340782 [Abstract] [PDF]  

Xing Zeng, Yuanhui Deng, Yi Feng, Yiming Liu, Liu Yang, Yu Huang, Jing Sun, Weixiong Liang, and Yongyuan Guan

Pharmacokinetics and Safety of Ginsenoside Rd Following a Single or Multiple Intravenous Dose in Healthy Chinese Volunteers
J Clin Pharmacol first published on November 25, 2009 as doi:10.1177/0091270009344334 [Abstract] [PDF]  

Mitsushige Sugimoto, Masafumi Nishino, Chise Kodaira, Mihoko Yamade, Mutsuhiro Ikuma, Tatsuo Tanaka, Haruhiko Sugimura, Akira Hishida, and Takahisa Furuta

Esophageal Mucosal Injury With Low-Dose Aspirin and Its Prevention by Rabeprazole
J Clin Pharmacol first published on November 25, 2009 as doi:10.1177/0091270009344983 [Abstract] [PDF]  

Andrej Skerjanec, Jixian Wang, Kelly Maren, and Lisa Rojkjaer

Investigation of the Pharmacokinetic Interactions of Deferasirox, a Once-Daily Oral Iron Chelator, With Midazolam, Rifampin, and Repaglinide in Healthy Volunteers
J Clin Pharmacol first published on November 25, 2009 as doi:10.1177/0091270009340418 [Abstract] [PDF]  

November 23, 2009

Jessie Gu, Adele Noe, Priya Chandra, Suliman Al-Fayoumi, Monica Ligueros-Saylan, Ramesh Sarangapani, Suzanne Maahs, Gary Ksander, Dean F. Rigel, Arco Y. Jeng, Tsu-Han Lin, Weiyi Zheng, and William P. Dole

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor–Neprilysin Inhibitor (ARNi)
J Clin Pharmacol first published on November 23, 2009 as doi:10.1177/0091270009343932 [Abstract] [PDF]  

Ulrike Werner, Dierk Werner, Svetlana Heinbüchner, Bernhard Graf, Hüseyin Ince, Stefan Kische, Petra Thürmann, Jörg König, Martin F. Fromm, and Oliver Zolk

Gender Is an Important Determinant of the Disposition of the Loop Diuretic Torasemide
J Clin Pharmacol first published on November 23, 2009 as doi:10.1177/0091270009337514 [Abstract] [PDF]  

Pawe Wiczling, Michael Rosenzweig, Louis Vaickus, and William J. Jusko

Pharmacokinetics and Pharmacodynamics of a Chimeric/Humanized Anti-CD3 Monoclonal Antibody, Otelixizumab (TRX4), in Subjects With Psoriasis and With Type 1 Diabetes Mellitus
J Clin Pharmacol first published on November 23, 2009 as doi:10.1177/0091270009349376 [Abstract] [PDF]  

Honghui Zhou, Chuanpu Hu, Yaowei Zhu, Ming Lu, Sam Liao, Newman Yeilding, and Hugh M. Davis

Population-Based Exposure-Efficacy Modeling of Ustekinumab in Patients With Moderate to Severe Plaque Psoriasis
J Clin Pharmacol first published on November 23, 2009 as doi:10.1177/0091270009343695 [Abstract] [PDF]  

November 13, 2009

Anne N. Nafziger and Joseph S. Bertino Jr.

Desirudin Dosing and Monitoring in Moderate Renal Impairment
J Clin Pharmacol first published on November 13, 2009 as doi:10.1177/0091270009350626 [Abstract] [PDF]  

Dave Singh, Lucy Smyth, Zoe Borrill, Lisa Sweeney, and Ruth Tal-Singer

A Randomized, Placebo-Controlled Study of the Effects of the p38 MAPK Inhibitor SB-681323 on Blood Biomarkers of Inflammation in COPD Patients
J Clin Pharmacol first published on November 13, 2009 as doi:10.1177/0091270009347873 [Abstract] [PDF]  

Daniel A. Spyker, Patrik Munzar, and James V. Cassella

Pharmacokinetics of Loxapine Following Inhalation of a Thermally Generated Aerosol in Healthy Volunteers
J Clin Pharmacol first published on November 13, 2009 as doi:10.1177/0091270009347866 [Abstract] [PDF]  

November 6, 2009

Heather E. Vezina, Henry H. Balfour Jr, Dennis R. Weller, Bruce J. Anderson, and Richard Brundage

Valacyclovir Pharmacokinetics and Exploratory Pharmacodynamics in Young Adults With Epstein-Barr Virus Infectious Mononucleosis
J Clin Pharmacol first published on November 6, 2009 as doi:10.1177/0091270009351884 [Abstract] [PDF]  

Martin C. S. Wong, Johnny Y. Jiang, and Sian M. Griffiths

Antihypertensive Drug Adherence Among 6408 Chinese Patients on Angiotensin-Converting Enzyme Inhibitors in Hong Kong: A Cohort Study
J Clin Pharmacol first published on November 6, 2009 as doi:10.1177/0091270009346058 [Abstract] [PDF]  

Tomoe Fujita, Yuji Kumagai, Ichimi Nakahara, Yoshio Ohtani, and Masataka Majima

Estimating the Contribution of Genes to Variation in Renal Drug Clearance by Active Secretion Using Multiple Data From Clinical Phase I Studies
J Clin Pharmacol first published on November 6, 2009 as doi:10.1177/0091270009348502 [PDF]  

October 30, 2009

Pankaj Gupta, Lena E. Friberg, Mats O. Karlsson, Sriram Krishnaswami, and Jonathan French

A Semi-Mechanistic Model of CP-690,550-Induced Reduction in Neutrophil Counts in Patients With Rheumatoid Arthritis
J Clin Pharmacol first published on October 30, 2009 as doi:10.1177/0091270009346060 [Abstract] [PDF]  

October 20, 2009

Karim Aouam, Foued Ben Romdhane, Chaouki Loussaief, Randa Salem, Adnène Toumi, Hichem Belhadjali, Amel Chaabane, Naceur A. Boughattas, and Mohamed Chakroun

Hypersensitivity Syndrome Induced by Anticonvulsants: Possible Cross-Reactivity Between Carbamazepine and Lamotrigine
J Clin Pharmacol first published on October 20, 2009 as doi:10.1177/0091270009344985 [Abstract] [PDF]  

Yuyan Jin, Bruce G. Pollock, Kim Coley, Del Miller, Stephen R. Marder, Jeff Florian, Lon Schneider, Jeff Lieberman, Margaret Kirshner, and Robert R. Bies

Population Pharmacokinetics of Perphenazine in Schizophrenia Patients From CATIE: Impact of Race and Smoking
J Clin Pharmacol first published on October 20, 2009 as doi:10.1177/0091270009343694 [Abstract] [PDF] [Appendix]  

October 19, 2009

Yuyan Jin, Bruce G. Pollock, Ellen Frank, Giovanni B. Cassano, Paola Rucci, Daniel J. Müller, James L. Kennedy, Rocco Nicola Forgione, Margaret Kirshner, Gail Kepple, Andrea Fagiolini, David J. Kupfer, and Robert R. Bies

Effect of Age, Weight, and CYP2C19 Genotype on Escitalopram Exposure
J Clin Pharmacol first published on October 19, 2009 as doi:10.1177/0091270009337946 [Abstract] [PDF]  

Jean-Luc Kienzler, Morris Gold, and Fabrice Nollevaux

Systemic Bioavailability of Topical Diclofenac Sodium Gel 1% Versus Oral Diclofenac Sodium in Healthy Volunteers
J Clin Pharmacol first published on October 19, 2009 as doi:10.1177/0091270009336234 [Abstract] [PDF]  

Ji-Hong Shon, Chang-Woo Yeo, Kwang-Hyeon Liu, Sang-Seop Lee, In-Jun Cha, and Jae-Gook Shin

Itraconazole and Rifampin Alter Significantly the Disposition and Antihistamine Effect of Ebastine and Its Metabolites in Healthy Participants
J Clin Pharmacol first published on October 19, 2009 as doi:10.1177/0091270009348974 [Abstract] [PDF]  

Roy L. Hawke, Sarah J. Schrieber, Tedi A. Soule, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Josh Berman, Qi-Ying Liu, Edward Doo, and Michael W. Fried

Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C
J Clin Pharmacol first published on October 19, 2009 as doi:10.1177/0091270009347475 [Abstract] [PDF]  

Yury Kaminsky, Alexander Suslikov, and Elena Kosenko

Specific and Pronounced Impacts of Lisinopril and Lisinopril Plus Simvastatin on Erythrocyte Antioxidant Enzymes
J Clin Pharmacol first published on October 19, 2009 as doi:10.1177/0091270009344854 [Abstract] [PDF]  

Willi Cawello, Brunhild Nickel, and Andrea Eggert-Formella

No Pharmacokinetic Interaction Between Lacosamide and Carbamazepine in Healthy Volunteers
J Clin Pharmacol first published on October 19, 2009 as doi:10.1177/0091270009347675 [Abstract] [PDF]  

October 16, 2009

Jing Li, Edward A. Sausville, Patrick J. Klein, David Morgenstern, Christopher P. Leamon, Richard A. Messmann, and Patricia LoRusso

Clinical Pharmacokinetics and Exposure-Toxicity Relationship of a Folate-Vinca Alkaloid Conjugate EC145 in Cancer Patients
J Clin Pharmacol first published on October 16, 2009 as doi:10.1177/0091270009339740 [Abstract] [PDF]  

Carole Giraud, Sandra Manceau, Xavier Declèves, François Goffinet, Jean-Pierre Morini, Hélène Chappuy, Frédéric Batteux, Sandrine Chouzenoux, Salah Yousif, Jean-Michel Scherrmann, Stéphane Blanche, and Jean-Marc Tréluyer

Influence of Development, HIV Infection, and Antiretroviral Therapies on the Gene Expression Profiles of ABC Transporters in Human Lymphocytes
J Clin Pharmacol first published on October 16, 2009 as doi:10.1177/0091270009343696 [Abstract] [PDF]  

Jie Ling, Honghui Zhou, Qun Jiao, and Hugh M. Davis

Interspecies Scaling of Therapeutic Monoclonal Antibodies: Initial Look
J Clin Pharmacol first published on October 16, 2009 as doi:10.1177/0091270009337134 [Abstract] [PDF]  

October 15, 2009

Brett Lauring, Victor Dishy, Wen-Lin Luo, Omar Laterza, Jaclyn Patterson, Josee Cote, Alice Chao, Patrick Larson, Maria Gutierrez, John A. Wagner, and Eseng Lai

Laropiprant in Combination With Extended-Release Niacin Does Not Alter Urine 11-Dehydrothromboxane B₂, a Marker of In Vivo Platelet Function, in Healthy, Hypercholesterolemic, and Diabetic Subjects
J Clin Pharmacol first published on October 15, 2009 as doi:10.1177/0091270009339593 [Abstract] [PDF]  

Fred Poordad, Gillian Zeldin, Stuart I. Harris, June Ke, Limin Xu, Douglas Mayers, and Xiao-Jian Zhou

Absence of Effect of Telbivudine on Cardiac Repolarization: Results of a Thorough QT/QTc Study in Healthy Participants
J Clin Pharmacol first published on October 15, 2009 as doi:10.1177/0091270009337943 [Abstract] [PDF]  

October 13, 2009

Majid Vakily, Jingtao Wu, and Stuart N. Atkinson

Lack of Electrocardiographic Effect of Dexlansoprazole MR, a Novel Modified-Release Formulation of the Proton Pump Inhibitor Dexlansoprazole, in Healthy Participants
J Clin Pharmacol first published on October 13, 2009 as doi:10.1177/0091270009339188 [Abstract] [PDF]  

October 6, 2009

Kelly K. Curtis, Jean T. Hartney, Roxanne C. Jewell, Jung W. Park, Peter F. Lebowitz, Pamela P. Griffin, Mitesh J. Borad, Tom R. Fitch, and Donald W. Northfelt

A Phase I Study to Characterize the Safety, Tolerability, and Pharmacokinetics of Topotecan at 4 mg/m² Administered Weekly as a 30-Minute Intravenous Infusion in Patients With Cancer
J Clin Pharmacol first published on October 6, 2009 as doi:10.1177/0091270009343699 [Abstract] [PDF]  

Zhi-hao Wang, Xiao-lin Liu, Ming Zhong, Li-ping Zhang, Yuan-yuan Shang, Xiao-yan Hu, Li Li, Yun Zhang, Jing-ti Deng, and Wei Zhang

Pleiotropic Effects of Atorvastatin on Monocytes in Atherosclerotic Patients
J Clin Pharmacol first published on October 6, 2009 as doi:10.1177/0091270009340889 [Abstract] [PDF]  

Norio Takahashi, Naoki Inui, Hiroshi Morita, Kazuhiko Takeuchi, Shinya Uchida, Hiroshi Watanabe, and Hirotoshi Nakamura

Effect of Thyroid Hormone on the Activity of CYP3A Enzyme in Humans
J Clin Pharmacol first published on October 6, 2009 as doi:10.1177/0091270009344336 [Abstract] [PDF]  

October 1, 2009

Virginia D. Schmith, Brendan M. Johnson, Lakshmi S. Vasist, Dennis L. Kelleher, Deborah A. Hewens, Malcolm A. Young, Vanessa Ameen, and George E. Dukes

The Effects of a Short Course of Antibiotics on Alvimopan and Metabolite Pharmacokinetics
J Clin Pharmacol first published on October 1, 2009 as doi:10.1177/0091270009347474 [Abstract] [PDF]  

Teresa Nunes, Luis Almeida, José-Francisco Rocha, Amílcar Falcão, Carlos Fernandes-Lopes, Ana I. Loureiro, Lyndon Wright, M. Vaz-da-Silva, and Patrício Soares-da-Silva

Pharmacokinetics of Trans-resveratrol Following Repeated Administration in Healthy Elderly and Young Subjects
J Clin Pharmacol first published on October 1, 2009 as doi:10.1177/0091270009339191 [PDF]  

Dyfrig A. Hughes and Jeffrey K. Aronson

A Systematic Review and Empirical Analysis of the Relation Between Dose and Duration of Drug Action
J Clin Pharmacol first published on October 1, 2009 as doi:10.1177/0091270008329555 [Abstract] [PDF]  

Khushnooma Y. Italia, Farah F. Jijina, Chandrakala S., Anita H. Nadkarni, Pratibha Sawant, Kanjaksha Ghosh, and Roshan B. Colah

Exposure to Hydroxyurea During Pregnancy in Sickle- Thalassemia: A Report of 2 Cases
J Clin Pharmacol first published on October 1, 2009 as doi:10.1177/0091270009343933 [Abstract] [PDF]  

September 30, 2009

Jill Chappell, Jingsong He, Mary Pat Knadler, Malcolm Mitchell, Douglas Lee, and Evelyn Lobo

Effects of Duloxetine on the Pharmacodynamics and Pharmacokinetics of Warfarin at Steady State in Healthy Subjects
J Clin Pharmacol first published on September 30, 2009 as doi:10.1177/0091270009344335 [Abstract] [PDF]  

Sreeraj Macha, Chan-Loi Yong, Thomas R. MacGregor, Mark Castles, Anne-Marie Quinson, Nicolas Rouyrre, and Ian Wilding

Assessment of Nevirapine Bioavailability From Targeted Sites in the Human Gastrointestinal Tract
J Clin Pharmacol first published on September 30, 2009 as doi:10.1177/0091270009344856 [Abstract] [PDF]  

September 29, 2009

Ilan Matok, Rafael Gorodischer, Gideon Koren, Eyal Sheiner, Arnon Wiznitzer, Elya Uziel, and Amalia Levy

The Safety of H₂-Blockers Use During Pregnancy
J Clin Pharmacol first published on September 29, 2009 as doi:10.1177/0091270009350483 [Abstract] [PDF]  

Kenji Momo, Masato Homma, Yoshiko Osaka, Shin-ichi Inomata, Makoto Tanaka, and Yukinao Kohda

Effects of Mexiletine, a CYP1A2 Inhibitor, on Tizanidine Pharmacokinetics and Pharmacodynamics
J Clin Pharmacol first published on September 29, 2009 as doi:10.1177/0091270009341961 [Abstract] [PDF]  

Karen S. Brown, Ingrid C. Armstrong, Antonia Wang, Joseph R. Walker, Robert J. Noveck, Dennis Swearingen, Mark Allison, James C. Kissling, James Kisicki, and Daniel E. Salazar

Effect of the Bile Acid Sequestrant Colesevelam on the Pharmacokinetics of Pioglitazone, Repaglinide, Estrogen Estradiol, Norethindrone, Levothyroxine, and Glyburide
J Clin Pharmacol first published on September 29, 2009 as doi:10.1177/0091270009349378 [Abstract] [PDF] [Supplementary Tables]  

David J. Greenblatt

Analysis of Drug Interactions Involving Fruit Beverages and Organic Anion-Transporting Polypeptides
J Clin Pharmacol first published on September 29, 2009 as doi:10.1177/0091270009342251 [Abstract] [PDF]  

Zuzana Motovska and Petr Widimsky

Clopidogrel Before Elective Percutaneous Coronary Intervention
J Clin Pharmacol first published on September 29, 2009 as doi:10.1177/0091270009348975 [Abstract] [PDF]  

September 24, 2009

Reza Khosravan, Melvin Toh, May Garrett, JoAnn La Fargue, Grace Ni, Thomas C. Marbury, Suzanne K. Swan, Norman M. Lunde, and Carlo L. Bello

Pharmacokinetics and Safety of Sunitinib Malate in Subjects With Impaired Renal Function
J Clin Pharmacol first published on September 24, 2009 as doi:10.1177/0091270009347868 [Abstract] [PDF]  

Wendell S. Akers, Jennifer J. Oh, Julie H. Oestreich, Suellen Ferraris, Mary Wethington, and Steven R. Steinhubl

Pharmacokinetics and Pharmacodynamics of a Bolus and Infusion of Cangrelor: A Direct, Parenteral P2Y12 Receptor Antagonist
J Clin Pharmacol first published on September 24, 2009 as doi:10.1177/0091270009344986 [Abstract] [PDF]  

September 23, 2009

Xiao-Jian Zhou, R. Colin Garner, Sheila Nicholson, C. James Kissling, and Douglas Mayers

Microdose Pharmacokinetics of IDX899 and IDX989, Candidate HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors, Following Oral and Intravenous Administration in Healthy Male Subjects
J Clin Pharmacol first published on September 23, 2009 as doi:10.1177/0091270009343698 [Abstract] [PDF]  

September 22, 2009

Jean-Francois Marier, Mohamad-Samer Mouksassi, Nathalie H. Gosselin, Martin Beliveau, Jane Cyran, and John Wallens

Population Pharmacokinetics of Teduglutide Following Repeated Subcutanenous Administrations in Healthy Participants and in Patients With Short Bowel Syndrome and Crohn's Disease
J Clin Pharmacol first published on September 22, 2009 as doi:10.1177/0091270009342252 [Abstract] [PDF]  

September 15, 2009

Juha Grönlund, Teijo Saari, Nora Hagelberg, Ilkka K. Martikainen, Pertti J. Neuvonen, Klaus T. Olkkola, and Kari Laine

Effect of Telithromycin on the Pharmacokinetics and Pharmacodynamics of Oral Oxycodone
J Clin Pharmacol first published on September 15, 2009 as doi:10.1177/0091270009336444 [Abstract] [PDF]  

July 17, 2009

Sean Hennessy, Charles E. Leonard, Cristin P. Freeman, Joshua P. Metlay, Xin Chu, Brian L. Strom, and Warren B. Bilker

CYP2C9, CYP2C19, and ABCB1 Genotype and Hospitalization for Phenytoin Toxicity
J Clin Pharmacol first published on July 17, 2009 as doi:10.1177/0091270009343006 [PDF]