Regulatory Science:

Alan M. Hochberg, Manfred Hauben, Ronald K. Pearson, Donald J. O'Hara, and Stephanie J. Reisinger

Systematic Investigation of Time Windows for Adverse Event Data Mining for Recently Approved Drugs
J Clin Pharmacol 2009 49: 626 -633. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics and Pharmacodynamics:

Nishit B. Modi, Rajneesh Nath, Peter Staehr, Suneel K. Gupta, Joseph W. Aquilina, and David Rivas

Pharmacokinetic, Pharmacodynamic, and Electrocardiographic Effects of Dapoxetine and Moxifloxacin Compared With Placebo in Healthy Adult Male Subjects
J Clin Pharmacol 2009 49: 634 -642. [Abstract] [Full Text] [PDF] [Request Permission]

Arie Katz, Chandrasekhar Udata, Elyssa Ott, Lisa Hickey, Michael E. Burczynski, Peter Burghart, Ole Vesterqvist, and Xu Meng

Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR-623, a Novel Liver X-Receptor Agonist, in Healthy Participants
J Clin Pharmacol 2009 49: 643 -649. [Abstract] [Full Text] [PDF] [Request Permission]

William L. Dahut, Jeanny B. Aragon-Ching, Sukyung Woo, Tanyifor M. Tohnya, James L. Gulley, Philip M. Arlen, John J. Wright, Jurgen Ventiz, and William D. Figg

Phase I Study of Oral Lenalidomide in Patients With Refractory Metastatic Cancer
J Clin Pharmacol 2009 49: 650 -660. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics:

Linghui Li, Seok Hwee Koo, Lie Michael George Limenta, Li Han, Khadijah Binte Hashim, Hung Hiang Quek, and Edmund Jon Deoon Lee

Effect of Dietary Purines on the Pharmacokinetics of Orally Administered Ribavirin
J Clin Pharmacol 2009 49: 661 -667. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacodynamics:

Candace Y. W. Lee, Horng H. Chen, Ondrej Lisy, Suzanne Swan, Courtney Cannon, Hsiao D. Lieu, and John C. Burnett, Jr.

Pharmacodynamics of a Novel Designer Natriuretic Peptide, CD-NP, in a First-in-Human Clinical Trial in Healthy Subjects
J Clin Pharmacol 2009 49: 668 -673. [Abstract] [Full Text] [PDF] [Request Permission]

Qualitative Clinical Pharmacology:

Marek Malik, Katerina Hnatkova, Anna Schmidt, and Peter Smetana

Electrocardiographic QTc Changes Due to Moxifloxacin Infusion
J Clin Pharmacol 2009 49: 674 -683. [Abstract] [Full Text] [PDF] [Request Permission]

Drug Interactions:

Wai-Ping Yau, Anantharaman Vathsala, Huei-Xin Lou, Shufeng Zhou, and Eli Chan

Mechanism-Based Enterohepatic Circulation Model of Mycophenolic Acid and Its Glucuronide Metabolite: Assessment of Impact of Cyclosporine Dose in Asian Renal Transplant Patients
J Clin Pharmacol 2009 49: 684 -699. [Abstract] [Full Text] [PDF] [Request Permission]

Timothy Eley, Feng R. Luo, Shruti Agrawal, Ashish Sanil, James Manning, Tong Li, Anne Blackwood-Chirchir, and Richard Bertz

Phase I Study of the Effect of Gastric Acid pH Modulators on the Bioavailability of Oral Dasatinib in Healthy Subjects
J Clin Pharmacol 2009 49: 700 -709. [Abstract] [Full Text] [PDF] [Request Permission]

Takafumi Naito, Yasuaki Mino, Atsushi Otsuka, Tomomi Ushiyama, Toshiki Ito, Seiichiro Ozono, Yoshiyuki Kagawa, and Junichi Kawakami

Impact of Calcineurin Inhibitors on Urinary Excretion of Mycophenolic Acid and Its Glucuronide in Kidney Transplant Recipients
J Clin Pharmacol 2009 49: 710 -718. [Abstract] [Full Text] [PDF] [Request Permission]

Duncan B. Richards, Gennyne A. Walker, Arun Mandagere, Mindy H. Magee, and Linda S. Henderson

Effect of Ketoconazole on the Pharmacokinetic Profile of Ambrisentan
J Clin Pharmacol 2009 49: 719 -724. [Abstract] [Full Text] [PDF] [Request Permission]

Special Populations/Renal Insufficiency:

Xiao-Jian Zhou, June Ke, William M. Sallas, Colm Farrell, Douglas L. Mayers, and Helen S. Pentikis

Population Pharmacokinetics of Telbivudine and Determination of Dose Adjustment for Patients With Renal Impairment
J Clin Pharmacol 2009 49: 725 -734. [Abstract] [Full Text] [PDF] [Request Permission]

Clinical Studies:

Patricia Nguyen, Martin Thomas, and Gideon Koren

Predictors of Prenatal Multivitamin Adherence in Pregnant Women
J Clin Pharmacol 2009 49: 735 -742. [Abstract] [Full Text] [PDF] [Request Permission]

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