Therapeutic Review:

Brian F. McBride

The Emerging Role of Antiarrhythmic Compounds With Atrial Selectivity in the Management of Atrial Fibrillation
J Clin Pharmacol 2009 49: 258 -267. [Abstract] [Full Text] [PDF] [Request Permission]

Regulatory Sciences:

Alex Kudrin

Challenges in the Clinical Development Requirements for the Marketing Authorization of New Medicines in Southeast Asia
J Clin Pharmacol 2009 49: 268 -280. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics and Pharmacodynamics:

B. J. Van der Schueren, M. W. Lunnon, B. E. Laurijssens, F. Guillard, J. Palmer, A. Van Hecken, M. Depré, F. H. Vanmolkot, and J. N. de Hoon

Does the Unfavorable Pharmacokinetic and Pharmacodynamic Profile of the iNOS Inhibitor GW273629 Lead to Inefficacy in Acute Migraine?
J Clin Pharmacol 2009 49: 281 -290. [Abstract] [Full Text] [PDF] [Request Permission]

Bharat Damle, Cecilia Fosser, Kaori Ito, Anh Tran, Pamela Clax, Howard Uderman, and Paul Glue

Effects of Standard and Supratherapeutic Doses of Nelfinavir on Cardiac Repolarization: A Thorough QT Study
J Clin Pharmacol 2009 49: 291 -300. [Abstract] [Full Text] [PDF] [Request Permission]

Clinical Studies:

Spencer Ling, Richard Z. Lewanczuk, Anthony S. Russell, Brendan Ihejirika, and Fakhreddin Jamali

Influence of Controlled Rheumatoid Arthritis on the Action and Disposition of Verapamil: Focus on Infliximab
J Clin Pharmacol 2009 49: 301 -311. [Abstract] [Full Text] [PDF] [Request Permission]

J. Christoph Geller, Kenneth Egstrup, Piotr Kulakowski, Mårten Rosenqvist, Maria Aunes Jansson, Anders Berggren, Nils Edvardsson, Philip Sager, and Harry J. Crijns

Rapid Conversion of Persistent Atrial Fibrillation to Sinus Rhythm by Intravenous AZD7009
J Clin Pharmacol 2009 49: 312 -322. [Abstract] [Full Text] [PDF] [Request Permission]

Quantitative Clinical Pharmacology:

Stefanie Hennig, Joakim Nyberg, Andrew C. Hooker, and Mats O. Karlsson

Trial Treatment Length Optimization With an Emphasis on Disease Progression Studies
J Clin Pharmacol 2009 49: 323 -335. [Abstract] [Full Text] [PDF] [Request Permission]

Mahesh N. Samtani, Juan Jose Perez-Ruixo, Kathryn H. Brown, Dirk Cerneus, and Christopher J. Molloy

Pharmacokinetic and Pharmacodynamic Modeling of Pegylated Thrombopoietin Mimetic Peptide (PEG-TPOm) After Single Intravenous Dose Administration in Healthy Subjects
J Clin Pharmacol 2009 49: 336 -350. [Abstract] [Full Text] [PDF] [Request Permission]

Drug Interactions:

Ping Zhao, Isabelle Ragueneau-Majlessi, Lei Zhang, John M. Strong, Kellie S. Reynolds, Rene H. Levy, Kenneth E. Thummel, and Shiew-Mei Huang

Quantitative Evaluation of Pharmacokinetic Inhibition of CYP3A Substrates by Ketoconazole: A Simulation Study
J Clin Pharmacol 2009 49: 351 -359. [Abstract] [Full Text] [PDF] [Request Permission]

David R. Foster, Shiyin Yee, Barry E. Bleske, Peggy L. Carver, Michael J. Shea, Sujatha S. Menon, Chandrasekharan Ramachandran, Lynda S. Welage, and Gordon L. Amidon

Lack of Interaction Between the Peptidomimetic Substrates Captopril and Cephradine
J Clin Pharmacol 2009 49: 360 -367. [Abstract] [Full Text] [PDF] [Request Permission]

Letter to the Editor:

Charles Oo and Ya-Chi Chen

The Need for Multiple Doses of 400 mg Ketoconazole as a Precipitant Inhibitor of a CYP3A Substrate in an In Vivo Drug-Drug Interaction Study
J Clin Pharmacol 2009 49: 368 -369. [Full Text] [PDF] [Request Permission]

Shiew-Mei Huang and Lawrence J. Lesko

Authors' Response
J Clin Pharmacol 2009 49: 370 . [Full Text] [PDF] [Request Permission]

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