Therapeutic Review:

Michelle Bestic, Martha Blackford, and Michael Reed

Fomepizole: A Critical Assessment of Current Dosing Recommendations
J Clin Pharmacol 2009 49: 130 -137. [Abstract] [Full Text] [PDF] [Request Permission]

Regulatory Science:

Myong-Jin Kim, Shiew-Mei Huang, Urs A. Meyer, Atiqur Rahman, and Lawrence J. Lesko

A Regulatory Science Perspective on Warfarin Therapy: A Pharmacogenetic Opportunity
J Clin Pharmacol 2009 49: 138 -146. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics:

Cyrus Ghobadi, Nahid Mirhosseini, Mohammad Reza Shiran, Ali Moghadamnia, Martin S. Lennard, William L. Ledger, and Amin Rostami-Hodjegan

Single-Dose Pharmacokinetic Study of Clomiphene Citrate Isomers in Anovular Patients With Polycystic Ovary Disease
J Clin Pharmacol 2009 49: 147 -154. [Abstract] [Full Text] [PDF] [Request Permission]

Mark W. Hull, Marianne Harris, Viviane Lima, Silvia Guillemi, P. Richard Harrigan, and Julio S. G. Montaner

Lopinavir/Ritonavir Pharmacokinetics in a Substitution of High-Dose Soft-Gelatin Capsule to Tablet Formulation
J Clin Pharmacol 2009 49: 155 -161. [Abstract] [Full Text] [PDF] [Request Permission]

Quantitative Clinical Pharmacology:

Yaowei Zhu, Chuanpu Hu, Ming Lu, Sam Liao, Joseph C. Marini, Jennifer Yohrling, Newman Yeilding, Hugh M. Davis, and Honghui Zhou

Population Pharmacokinetic Modeling of Ustekinumab, a Human Monoclonal Antibody Targeting IL-12/23p40, in Patients With Moderate to Severe Plaque Psoriasis
J Clin Pharmacol 2009 49: 162 -175. [Abstract] [Full Text] [PDF] [Request Permission]

Yuyan Jin, Bruce G. Pollock, Ellen Frank, Jeff Florian, Margaret Kirshner, Andrea Fagiolini, David J. Kupfer, Marc R. Gastonguay, Gail Kepple, Yan Feng, and Robert R. Bies

The Effect of Reporting Methods for Dosing Times on the Estimation of Pharmacokinetic Parameters of Escitalopram
J Clin Pharmacol 2009 49: 176 -184. [Abstract] [Full Text] [PDF] [Request Permission]

Wai-Johnn Sam, Fatemeh Akhlaghi, and Sara E. Rosenbaum

Population Pharmacokinetics of Mycophenolic Acid and Its 2 Glucuronidated Metabolites in Kidney Transplant Recipients
J Clin Pharmacol 2009 49: 185 -195. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacogenomics:

Johanna Weiss, Magdalena Maria ten Hoevel, Jürgen Burhenne, Ingeborg Walter-Sack, Michael Marcus Hoffmann, Jens Rengelshausen, Walter E. Haefeli, and Gerd Mikus

CYP2C19 Genotype Is a Major Factor Contributing to the Highly Variable Pharmacokinetics of Voriconazole
J Clin Pharmacol 2009 49: 196 -204. [Abstract] [Full Text] [PDF] [Request Permission]

Drug Interactions:

Vanessa Bergamin Boralli, Eduardo Barbosa Coelho, Stefânia Amaral Sampaio, Maria Paula Marques, and Vera Lucia Lanchote

Enantioselectivity in the Pharmacokinetic Interaction Between Fluvastatin and Lercanidipine in Healthy Volunteers
J Clin Pharmacol 2009 49: 205 -211. [Abstract] [Full Text] [PDF] [Request Permission]

John M. Kovarik, Kiran Dole, Gilles-Jacques Riviere, Francoise Pommier, Steve Maton, Yi Jin, Kenneth C. Lasseter, and Robert L. Schmouder

Ketoconazole Increases Fingolimod Blood Levels in a Drug Interaction via CYP4F2 Inhibition
J Clin Pharmacol 2009 49: 212 -218. [Abstract] [Full Text] [PDF] [Request Permission]

Alice I. Nichols, Penny Fatato, Magdy Shenouda, Jeffrey Paul, Jennifer A. Isler, Ronald D. Pedersen, Qin Jiang, Saeeduddin Ahmed, and Albena Patroneva

The Effects of Desvenlafaxine and Paroxetine on the Pharmacokinetics of the Cytochrome P450 2D6 Substrate Desipramine in Healthy Adults
J Clin Pharmacol 2009 49: 219 -228. [Abstract] [Full Text] [PDF] [Request Permission]

Biologics:

Morten A. Karsdal, Inger Byrjalsen, Kim Henriksen, Bente J. Riis, and Claus Christiansen

A Pharmacokinetic and Pharmacodynamic Comparison of Synthetic and Recombinant Oral Salmon Calcitonin
J Clin Pharmacol 2009 49: 229 -234. [Abstract] [Full Text] [PDF] [Request Permission]

Pediatrics:

Jeffrey Blumer, Donald L. Batisky, Thomas Wells, Victor Shi, Susan Solar-Yohay, and Gangadhar Sunkara

Pharmacokinetics of Valsartan in Pediatric and Adolescent Subjects With Hypertension
J Clin Pharmacol 2009 49: 235 -241. [Abstract] [Full Text] [PDF] [Request Permission]

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