Review:

José Juan Escobar-Chávez, Dalia Bonilla-Martínez, Martha Angélica Villegas-González, and Alma Luisa Revilla-Vázquez

Electroporation as an Efficient Physical Enhancer for Skin Drug Delivery
J Clin Pharmacol 2009 49: 1262 -1283. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics and Pharmacodynamics:

Shashank Rohatagi, Timothy J. Carrothers, Jon Kuwabara-Wagg, and Tatiana Khariton

Is a Thorough QTc Study Necessary? The Role of Modeling and Simulation in Evaluating the QTc Prolongation Potential of Drugs
J Clin Pharmacol 2009 49: 1284 -1296. [Abstract] [Full Text] [PDF] [Appendix] [Request Permission]

Sunny Chapel, Matt M. Hutmacher, George Haig, Howard Bockbrader, Rik de Greef, Sheldon H. Preskorn, and Richard L. Lalonde

Exposure-Response Analysis in Patients With Schizophrenia to Assess the Effect of Asenapine on QTc Prolongation
J Clin Pharmacol 2009 49: 1297 -1308. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics:

Takafumi Ide, Tomohiro Sasaki, Kazuya Maeda, Shun Higuchi, Yuichi Sugiyama, and Ichiro Ieiri

Quantitative Population Pharmacokinetic Analysis of Pravastatin Using an Enterohepatic Circulation Model Combined With Pharmacogenomic Information on SLCO1B1 and ABCC2 Polymorphisms
J Clin Pharmacol 2009 49: 1309 -1317. [Abstract] [Full Text] [PDF] [Request Permission]

Sandra Boom, Krishna Talluri, Luc Janssens, Bart Remmerie, Marc De Meulder, Stefaan Rossenu, Nancy van Osselaer, Marielle Eerdekens, and Adriaan Cleton

Single- and Multiple-Dose Pharmacokinetics and Dose Proportionality of the Psychotropic Agent Paliperidone Extended Release
J Clin Pharmacol 2009 49: 1318 -1330. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacodynamics:

Claus Graff, Jørgen Matz, Ellen B. Christensen, Mads P. Andersen, Jørgen K. Kanters, Egon Toft, Steen Pehrson, Thomas B. Hardahl, Jimmi Nielsen, and Johannes J. Struijk

Quantitative Analysis of T-wave Morphology Increases Confidence in Drug-Induced Cardiac Repolarization Abnormalities: Evidence From the Investigational I_Kr Inhibitor Lu 35-138
J Clin Pharmacol 2009 49: 1331 -1342. [Abstract] [Full Text] [PDF] [Request Permission]

Ekkehard Gruenig, Evangelos Michelakis, Jean-Luc Vachiéry, Carmine Dario Vizza, F. Joachim Meyer, Martin Doelberg, Doris Bach, Jasper Dingemanse, and Nazzareno Galiè

Acute Hemodynamic Effects of Single-Dose Sildenafil When Added to Established Bosentan Therapy in Patients With Pulmonary Arterial Hypertension: Results of the COMPASS-1 Study
J Clin Pharmacol 2009 49: 1343 -1352. [Abstract] [Full Text] [PDF] [Request Permission]

Dhruba J. Chatterjee, Naum Khutoryansky, Milan Zdravkovic, Craig R. Sprenger, and Jeffrey S. Litwin

Absence of QTc Prolongation in a Thorough QT Study With Subcutaneous Liraglutide, a Once-Daily Human GLP-1 Analog for Treatment of Type 2 Diabetes
J Clin Pharmacol 2009 49: 1353 -1362. [Abstract] [Full Text] [PDF] [Request Permission]

Drug Interactions:

Simon Haroutiunian, Yael Ratz, Bella Rabinovich, Miriam Adam, and Amnon Hoffman

Valproic Acid Plasma Concentration Decreases in a Dose-Independent Manner Following Administration of Meropenem: A Retrospective Study
J Clin Pharmacol 2009 49: 1363 -1369. [Abstract] [Full Text] [PDF] [Request Permission]

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