Clinical Studies:

Jean-Philippe Couderc, Stefan Kaab, Martin Hinterseer, Scott McNitt, Xiaojuan Xia, Anthony Fossa, Britt M. Beckmann, Slava Polonsky, and Wojciech Zareba

Baseline Values and Sotalol-Induced Changes of Ventricular Repolarization Duration, Heterogeneity, and Instability in Patients With a History of Drug-Induced Torsades de Pointes
J Clin Pharmacol 2009 49: 6 -16. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacogenomics:

Zhongping L. Mao, Jeffery J. Wheeler, Lilian Clohs, Gregory N. Beatch, and James Keirns

Pharmacokinetics of Novel Atrial-Selective Antiarrhythmic Agent Vernakalant Hydrochloride Injection (RSD1235): Influence of CYP2D6 Expression and Other Factors
J Clin Pharmacol 2009 49: 17 -29. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics and Pharmcodynamics:

J. Michael Hamilton, Matthew W. Harding, Thomas Genna, and David K. Bol

A Phase I Dose-Ranging Study of the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of AVN944, an IMPDH Inhibitor, in Healthy Male Volunteers
J Clin Pharmacol 2009 49: 30 -38. [Abstract] [Full Text] [PDF] [Request Permission]

Pei Hu, Qi Yin, Fabienne Deckert, Ji Jiang, Dongyang Liu, Lise Kjems, William P. Dole, and Yan-Ling He

Pharmacokinetics and Pharmacodynamics of Vildagliptin in Healthy Chinese Volunteers
J Clin Pharmacol 2009 49: 39 -49. [Abstract] [Full Text] [PDF] [Request Permission]

Quantitative Clinical Pharmacology:

Shashank Rohatagi, Hamim Zahir, James B. Moberly, Kenneth E. Truitt, Shin-ichi Inaba, Takaichi Shimozato, and T. J. Carrothers

Use of an Exposure-Response Model to Aid Early Drug Development of an Oral Sphingosine 1-Phosphate Receptor Modulator
J Clin Pharmacol 2009 49: 50 -62. [Abstract] [Full Text] [PDF] [Request Permission]

Drug Interactions:

Tong Zhu, Walid M. Awni, Balakrishna Hosmane, Maureen T. Kelly, Darryl J. Sleep, James C. Stolzenbach, Katty Wan, Titus O. Chira, and Rajendra S. Pradhan

ABT-335, the Choline Salt of Fenofibric Acid, Does Not Have a Clinically Significant Pharmacokinetic Interaction With Rosuvastatin in Humans
J Clin Pharmacol 2009 49: 63 -71. [Abstract] [Full Text] [PDF] [Request Permission]

Jules I. Schwartz, Stephanie Dunbar, Jinyu Yuan, Susie Li, Deborah L. Miller, Kim Rosko, Amy O. Johnson-Levonas, Kenneth C. Lasseter, and John A. Wagner

Influence of Taranabant, an Orally Active, Highly Selective, Potent Cannabinoid-1 Receptor (CB1R) Inverse Agonist, on Ethinyl Estradiol and Norelgestromin Plasma Pharmacokinetics
J Clin Pharmacol 2009 49: 72 -79. [Abstract] [Full Text] [PDF] [Request Permission]

Rajesh Krishna, Arthur J. Bergman, Bo Jin, Amit Garg, Brad Roadcap, Rita Chiou, James Dru, Josee Cote, Tine Laethem, Regina W. Wang, Varsha Didolkar, Eva Vets, Keith Gottesdiener, and John A. Wagner

Assessment of the CYP3A-Mediated Drug Interaction Potential of Anacetrapib, a Potent Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Volunteers
J Clin Pharmacol 2009 49: 80 -87. [Abstract] [Full Text] [PDF] [Request Permission]

Pediatrics:

Jeannine S. McCune, David H. Salinger, Paolo Vicini, Celeste Oglesby, David K. Blough, and Julie R. Park

Population Pharmacokinetics of Cyclophosphamide and Metabolites in Children With Neuroblastoma: A Report From the Children's Oncology Group
J Clin Pharmacol 2009 49: 88 -102. [Abstract] [Full Text] [PDF] [Request Permission]

Brief Report/Clinical Studies:

Nenad Sarapa, Steven F. Francom, Sara M. Azzam, Prachi K. Wickremasingha, and Benoit Tyl

Detection of Clinically Significant QTc Prolongation in Phase I Studies in Healthy Participants: Comparison of 2 Semiautomated QT Measurement Methods
J Clin Pharmacol 2009 49: 103 -108. [Full Text] [PDF] [Request Permission]

Franz X. Kleber, Tom Bollmann, Mathias M. Borst, Angelika Costard-Jäckle, Ralf Ewert, Matti Kivikko, Tiina Petterson, Pasi Pohjanjousi, Steffen Sonntag, and Gerhard Wikström

Repetitive Dosing of Intravenous Levosimendan Improves Pulmonary Hemodynamics in Patients With Pulmonary Hypertension: Results of a Pilot Study
J Clin Pharmacol 2009 49: 109 -115. [Full Text] [PDF] [Request Permission]

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