Pharmacokinetics and Pharmacodynamics:

Reza Khosravan, Michael J. Kukulka, Jing-Tao Wu, Nancy Joseph-Ridge, and Laurent Vernillet

The Effect of Age and Gender on Pharmacokinetics, Pharmacodynamics, and Safety of Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase
J Clin Pharmacol 2008 48: 1014 -1024. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics and Pharmacodynamics/Special Populations:

Bing-Bing Yang, Anna Kido, Margaret Salfi, Suzanne Swan, and John T. Sullivan

Pharmacokinetics and Pharmacodynamics of Pegfilgrastim in Subjects With Various Degrees of Renal Function
J Clin Pharmacol 2008 48: 1025 -1031. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacogenomics:

Awewura Kwara, Margaret Lartey, Kwamena W. Sagoe, Fafa Xexemeku, Ernest Kenu, Joseph Oliver-Commey, Vincent Boima, Augustine Sagoe, Isaac Boamah, David J. Greenblatt, and Michael H. Court

Pharmacokinetics of Efavirenz When Co-administered With Rifampin in TB/HIV Co-infected Patients: Pharmacogenetic Effect of CYP2B6 Variation
J Clin Pharmacol 2008 48: 1032 -1040. [Abstract] [Full Text] [PDF] [Request Permission]

J. Steven Leeder, Robin E. Pearce, Andrea Gaedigk, Anil Modak, and David I. Rosen

Evaluation of a [¹³C]-Dextromethorphan Breath Test to Assess CYP2D6 Phenotype
J Clin Pharmacol 2008 48: 1041 -1051. [Abstract] [Full Text] [PDF] [Request Permission]

Pediatrics:

L'Aurelle Johnson, Paul J. Orchard, K. Scott Baker, Richard Brundage, Qing Cao, Xinjing Wang, Erica Langer, Sharein Farag-El Maasah, Julie A. Ross, Rory Remmel, and Pamala A. Jacobson

Glutathione S-Transferase A1 Genetic Variants Reduce Busulfan Clearance in Children Undergoing Hematopoietic Cell Transplantation
J Clin Pharmacol 2008 48: 1052 -1062. [Abstract] [Full Text] [PDF] [Request Permission]

Quantitative Clinical Pharmacology:

James A. Dowell, Beth P. Goldstein, Mary Buckwalter, Martin Stogniew, and Bharat Damle

Pharmacokinetic-Pharmacodynamic Modeling of Dalbavancin, a Novel Glycopeptide Antibiotic
J Clin Pharmacol 2008 48: 1063 -1068. [Abstract] [Full Text] [PDF] [Request Permission]

Kai Wu, Navin Goyal, Jeffrey G. Stark, and Günther Hochhaus

Evaluation of the Administration Time Effect on the Cumulative Cortisol Suppression and Cumulative Lymphocytes Suppression for Once-Daily Inhaled Corticosteroids: A Population Modeling/Simulation Approach
J Clin Pharmacol 2008 48: 1069 -1080. [Abstract] [Full Text] [PDF] [Request Permission]

Clinical Impact:

Michael Neely and Roger Jelliffe

Practical Therapeutic Drug Management in HIV-Infected Patients: Use of Population Pharmacokinetic Models Supplemented by Individualized Bayesian Dose Optimization
J Clin Pharmacol 2008 48: 1081 -1091. [Abstract] [Full Text] [PDF] [Request Permission]

Drug Interactions:

N. Rao, B. Dvorchik, N. Sussman, H. Wang, K. Yamamoto, A. Mori, T. Uchimura, and P. Chaikin

A Study of the Pharmacokinetic Interaction of Istradefylline, a Novel Therapeutic for Parkinson's Disease, and Atorvastatin
J Clin Pharmacol 2008 48: 1092 -1098. [Abstract] [Full Text] [PDF] [Request Permission]

ACCP Announcements:

Abstracts: Thirty-Seventh Annual Meeting American College of Clinical Pharmacology September 14-16, 2008 Philadelphia, Pennsylvania
J Clin Pharmacol 2008 48: 1099 -1135. [PDF] [Request Permission]

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