Drug Interactions/Review:

Shiew-Mei Huang, John M. Strong, Lei Zhang, Kellie S. Reynolds, Srikanth Nallani, Robert Temple, Sophia Abraham, Sayed Al Habet, Raman K. Baweja, Gilbert J. Burckart, Sang Chung, Philip Colangelo, David Frucht, Martin D. Green, Paul Hepp, Elena Karnaukhova, Hon-Sum Ko, Jang-Ik Lee, Patrick J. Marroum, Janet M. Norden, Wei Qiu, Atiqur Rahman, Solomon Sobel, Toni Stifano, Kenneth Thummel, Xiao-xiong Wei, Sally Yasuda, Jenny H. Zheng, Hong Zhao, and Lawrence J. Lesko

New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process
J Clin Pharmacol 2008 48: 662 -670. [Abstract] [Full Text] [PDF] [Request Permission]

Drug Interactions:

Scott R. Penzak, Kristin H. Busse, Sarah M. Robertson, Elizabeth Formentini, Raul M. Alfaro, and Richard T. Davey, Jr.

Limitations of Using a Single Postdose Midazolam Concentration to Predict CYP3A-Mediated Drug Interactions
J Clin Pharmacol 2008 48: 671 -680. [Abstract] [Full Text] [PDF] [Request Permission]

Biologics:

Zhenhua Xu, Kathleen Seitz, Adedigbo Fasanmade, Joyce Ford, Paul Williamson, Weichun Xu, Hugh M. Davis, and Honghui Zhou

Population Pharmacokinetics of Infliximab in Patients With Ankylosing Spondylitis
J Clin Pharmacol 2008 48: 681 -695. [Abstract] [Full Text] [PDF] [Request Permission]

Quantitative Clinical Pharmacology:

Ying Hong, Shashank Rohatagi, Bahru Habtemariam, Joseph R. Walker, Sherwyn L. Schwartz, and Donald E. Mager

Population Exposure-Response Modeling of Metformin in Patients With Type 2 Diabetes Mellitus
J Clin Pharmacol 2008 48: 696 -707. [Abstract] [Full Text] [PDF] [Appendix] [Request Permission]

Corinne Seng Yue, William Huang, Michelle Alton, Allan N. Maroli, Royce W. Waltrip, David Wright, and Marika Di Marco

Population Pharmacokinetic and Pharmacodynamic Analysis of Pegloticase in Subjects With Hyperuricemia and Treatment-Failure Gout
J Clin Pharmacol 2008 48: 708 -718. [Abstract] [Full Text] [PDF] [Request Permission]

Jian Wang, Michael Weiss, and David Z. D'Argenio

A Note on Population Analysis of Dissolution-Absorption Models Using the Inverse Gaussian Function
J Clin Pharmacol 2008 48: 719 -725. [Abstract] [Full Text] [PDF] [Request Permission]

M. Iwamoto, J. T. Kost, G. C. Mistry, L. A. Wenning, S. A. Breidinger, T. C. Marbury, J. A. Stone, K. M. Gottesdiener, D. M. Bloomfield, and J. A. Wagner

Raltegravir Thorough QT/QTc Study: A Single Supratherapeutic Dose of Raltegravir Does Not Prolong the QTcF Interval
J Clin Pharmacol 2008 48: 726 -733. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacokinetics and Pharmacodynamics:

Carol Addy, Paul Rothenberg, Susie Li, Anup Majumdar, Nancy Agrawal, Hankun Li, Ling Zhong, Jinyu Yuan, Andrea Maes, Stephanie Dunbar, Josee Cote, Kim Rosko, Kristien Van Dyck, Inge De Lepeleire, Jan de Hoon, Anne Van Hecken, Marleen Depré, Annemie Knops, Keith Gottesdiener, Aubrey Stoch, and John Wagner

Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of Taranabant, a Novel Selective Cannabinoid-1 Receptor Inverse Agonist, in Healthy Male Volunteers
J Clin Pharmacol 2008 48: 734 -744. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacodynamics:

Jules I. Schwartz, Aimee L. Dallob, Patrick J. Larson, Omar F. Laterza, Jutta Miller, Jane Royalty, Karen M. Snyder, Derek L. Chappell, Deborah A. Hilliard, Mary E. Flynn, Paul F. Cavanaugh, Jr, and John A. Wagner

Comparative Inhibitory Activity of Etoricoxib, Celecoxib, and Diclofenac on COX-2 Versus COX-1 in Healthy Subjects
J Clin Pharmacol 2008 48: 745 -754. [Abstract] [Full Text] [PDF] [Request Permission]

Calvin Astry, Woubalem Birmachu, Lester I. Harrison, and Tze-Chiang Meng

Cutaneous Pharmacodynamics of a Toll-Like Receptor 7 Agonist, 852A, in Humans
J Clin Pharmacol 2008 48: 755 -762. [Abstract] [Full Text] [PDF] [Appendix] [Request Permission]

Pharmacokinetics:

Yanfeng Wang, Ophelia Q. P. Yin, Peter Graf, James C. Kisicki, and Horst Schran

Dose- and Time-Dependent Pharmacokinetics of Midostaurin in Patients With Diabetes Mellitus
J Clin Pharmacol 2008 48: 763 -775. [Abstract] [Full Text] [PDF] [Request Permission]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.