Biologics:

Ivan Nestorov, Alain Munafo, Orestis Papasouliotis, and Jennifer Visich

Pharmacokinetics and Biological Activity of Atacicept in Patients With Rheumatoid Arthritis
J Clin Pharmacol 2008 48: 406 -417. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Carol Addy, Susie Li, Nancy Agrawal, Julie Stone, Anup Majumdar, Ling Zhong, Hankun Li, Jinyu Yuan, Andrea Maes, Paul Rothenberg, Josee Cote, Kim Rosko, Corinne Cummings, Steven Warrington, Malcolm Boyce, Keith Gottesdiener, Aubrey Stoch, and John Wagner

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Properties of Taranabant, a Novel Selective Cannabinoid-1 Receptor Inverse Agonist, for the Treatment of Obesity: Results From a Double-Blind, Placebo-Controlled, Single Oral Dose Study in Healthy Volunteers
J Clin Pharmacol 2008 48: 418 -427. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

Renzo Galanello, Antonio Piga, Maria Domenica Cappellini, Gian Luca Forni, Antonella Zappu, Raffaella Origa, Catherine Dutreix, Rossella Belleli, John M. Ford, Gilles-Jacques Rivière, Sébastien Balez, Daniele Alberti, and Romain Séchaud

Effect of Food, Type of Food, and Time of Food Intake on Deferasirox Bioavailability: Recommendations for an Optimal Deferasirox Administration Regimen
J Clin Pharmacol 2008 48: 428 -435. [Abstract] [Full Text] [PDF]  

Craig Lehmann and Gerald L. Wannarka

Bioavailability and Dose Proportionality of Intramuscular Diazepam Administered by Autoinjector
J Clin Pharmacol 2008 48: 436 -444. [Abstract] [Full Text] [PDF]  

Pharmacokinetics/Special Populations:

Jaakko Puttonen, Sampo Kantele, Angela Ruck, Meri Ramela, Sari Häkkinen, Matti Kivikko, and Pertti J. Pentikäinen

Pharmacokinetics of Intravenous Levosimendan and Its Metabolites in Subjects With Hepatic Impairment
J Clin Pharmacol 2008 48: 445 -454. [Abstract] [Full Text] [PDF]  

Quantitative Clinical Pharmacology:

Baralee Punyawudho, R. Eugene Ramsay, Flavia M. Macias, A. James Rowan, Joseph F. Collins, Richard C. Brundage, and Angela K. Birnbaum

Population Pharmacokinetics of Lamotrigine in Elderly Patients
J Clin Pharmacol 2008 48: 455 -463. [Abstract] [Full Text] [PDF]  

Drug Metabolism:

Evan D. Kharasch, Darain Mitchell, and Rebecka Coles

Stereoselective Bupropion Hydroxylation as an In Vivo Phenotypic Probe for Cytochrome P4502B6 (CYP2B6) Activity
J Clin Pharmacol 2008 48: 464 -474. [Abstract] [Full Text] [PDF]  

Drug Interactions:

David S. Small, Nagy A. Farid, Christopher D. Payne, Govinda J. Weerakkody, Ying G. Li, John T. Brandt, Daniel E. Salazar, and Kenneth J. Winters

Effects of the Proton Pump Inhibitor Lansoprazole on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel
J Clin Pharmacol 2008 48: 475 -484. [Abstract] [Full Text] [PDF]  

Pediatrics:

Pamala Jacobson, Jaiyin Huang, Nancy Rydholm, MyHang Tran, Todd DeFor, Jakub Tolar, and Paul J. Orchard

Higher Mycophenolate Dose Requirements in Children Undergoing Hematopoietic Cell Transplant (HCT)
J Clin Pharmacol 2008 48: 485 -494. [Abstract] [Full Text] [PDF]  

Elina Kumpulainen, Hannu Kokki, Merja Laisalmi, Marja Heikkinen, Jouko Savolainen, Jarkko Rautio, and Marko Lehtonen

How Readily Does Ketorolac Penetrate Cerebrospinal Fluid in Children?
J Clin Pharmacol 2008 48: 495 -501. [Abstract] [Full Text] [PDF]  

Gregory L. Kearns, Susan Lu, Lata Maganti, Xiujiang (Susie) Li, Elizabeth Migoya, Tuli Ahmed, Barbara Knorr, and Theodore F. Reiss

Pharmacokinetics and Safety of Montelukast Oral Granules in Children 1 to 3 Months of Age With Bronchiolitis
J Clin Pharmacol 2008 48: 502 -511. [Abstract] [Full Text] [PDF]  

Etienne M. Sokal, Deirdre Kelly, Stefan Wirth, Jacob Mizerski, Anil Dhawan, and David Frederick

The Pharmacokinetics and Safety of Adefovir Dipivoxil in Children and Adolescents With Chronic Hepatitis B Virus Infection
J Clin Pharmacol 2008 48: 512 -517. [Abstract] [Full Text] [PDF]  

Regulatory Science:

Jennifer L. DiGiacinto, Kirk M. Chan-Tack, Sarah M. Robertson, Kellie S. Reynolds, and Kimberly A. Struble

Are Literature References Sufficient for Dose Recommendations? An FDA Case Study of Efavirenz and Rifampin
J Clin Pharmacol 2008 48: 518 -523. [Abstract] [Full Text] [PDF]  

Brief Report/Pharmacokinetics:

Guochuan E. Tsai, Hsien-Yuan Lane, Chad M. VanDenBerg, Yi-Ching Liu, Priscilla Tsai, and Michael W. Jann

Disposition of D-Serine in Healthy Adults
J Clin Pharmacol 2008 48: 524 -527. [Full Text] [PDF]  

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