Pharmacokinetics and Pharmacodynamics:

Marek Malik, Katerina Hnatkova, John Ford, and David Madge

Near-Thorough QT Study as Part of a First-In-Man Study
J Clin Pharmacol 2008 48: 1146 -1157. [Abstract] [Full Text] [PDF] [Request Permission]

Alan L. Myers, Vijay V. Upreti, Manoj Khurana, and Natalie D. Eddington

Characterization of Total Plasma Glycosaminoglycan Levels in Healthy Volunteers Following Oral Administration of a Novel Antithrombotic Odiparcil With Aspirin or Enoxaparin
J Clin Pharmacol 2008 48: 1158 -1170. [Abstract] [Full Text] [PDF] [Request Permission]

S. Hüttner, E. U. Graefe-Mody, B. Withopf, A. Ring, and K. A. Dugi

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of BI 1356, an Inhibitor of Dipeptidyl Peptidase 4, in Healthy Male Volunteers
J Clin Pharmacol 2008 48: 1171 -1178. [Abstract] [Full Text] [PDF] [Request Permission]

Pharmacodynamics:

James F. Demarest, Sara S. Sparks, Kathleen Schell, Shiro Shibayama, Charlene B. McDanal, Lei Fang, Kimberly K. Adkison, Anne Shachoy-Clark, and Stephen C. Piscitelli

In Vitro and Clinical Investigation of the Relationship Between CCR5 Receptor Occupancy and Anti-HIV Activity of Aplaviroc
J Clin Pharmacol 2008 48: 1179 -1188. [Abstract] [Full Text] [PDF] [Request Permission]

Biologics:

Karina Kuczka, Sebastian Harder, Bettina Picard-Willems, André Warnke, Frank Donath, Pietro Bianchini, Bruna Parma, and Henning Blume

Biomarkers and Coagulation Tests for Assessing the Biosimilarity of a Generic Low-Molecular-Weight Heparin: Results of a Study in Healthy Subjects With Enoxaparin
J Clin Pharmacol 2008 48: 1189 -1196. [Abstract] [Full Text] [PDF] [Request Permission]

Esther Bouman-Thio, Kari Franson, Bruce Miller, John Getsy, Adam Cohen, Stephen A. Bai, Jennifer Yohrling, Bart Frederick, Stanley Marciniak, Qun Jiao, Haishan Jang, Hugh Davis, and Jacobus Burggraaf

A Phase I, Single and Fractionated, Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of an Erythropoietin Mimetic Antibody Fusion Protein (CNTO 528) in Healthy Male Subjects
J Clin Pharmacol 2008 48: 1197 -1207. [Abstract] [Full Text] [PDF] [Request Permission]

Forum/Biologics:

Nikos Panayotatos

Drug-binding Cavities in Long-Lived Biologics: Cause for Concern but Also Potential Benefit
J Clin Pharmacol 2008 48: 1208 -1211. [Abstract] [Full Text] [PDF] [Request Permission]

Therapeutic Review:

Martin S. Rhee and David J. Greenblatt

Pharmacologic Consideration for the Use of Antiretroviral Agents in the Elderly
J Clin Pharmacol 2008 48: 1212 -1225. [Abstract] [Full Text] [PDF] [Request Permission]

Methods:

Kosalaram Goteti, Patrick J. Brassil, Steven S. Good, and C. Edwin Garner

Estimation of Human Drug Clearance Using Multiexponential Techniques
J Clin Pharmacol 2008 48: 1226 -1236. [Abstract] [Full Text] [PDF] [Request Permission]

Brief Report/Pharmacodynamics:

Rajesh Krishna, Peggy Wong, Catherine Stevens, Inge De Lepeleire, Kristien Van Dyck, Raymond C. Rosen, Isaias Noel Gendrano, III, Mathieu Peeters, John A. Wagner, and Gary A. Herman

Lack of Erectogenic Activity of a Novel Selective Melanocortin-4 Receptor Agonist in a Clinical Experimental Model
J Clin Pharmacol 2008 48: 1237 -1241. [Full Text] [PDF] [Request Permission]

Letter to the Editor:

Roger Jelliffe

Estimation of Creatinine Clearance
J Clin Pharmacol 2008 48: 1242 -1244. [Full Text] [PDF] [Request Permission]

J. Carlos Tutor

Author's Response
J Clin Pharmacol 2008 48: 1244 . [Full Text] [PDF] [Request Permission]

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