Commentaries:

Daniel Bloomfield and Rajesh Krishna

Commentary on the Clinical Relevance of Concentration/QTc Relationships for New Drug Candidates
J Clin Pharmacol 2008 48: 6. [Full Text] [PDF]  

Tanya Russell, Steven P. Riley, Jack A. Cook, and Richard L. Lalonde

A Perspective on the Use of Concentration-QT Modeling in Drug Development
J Clin Pharmacol 2008 48: 9. [Full Text] [PDF]  

Regulatory Science:

Christine E. Garnett, Nhi Beasley, V. Atul Bhattaram, Pravin R. Jadhav, Rajanikanth Madabushi, Norman Stockbridge, Christoffer W. Tornøe, Yaning Wang, Hao Zhu, and Jogarao V. Gobburu

Concentration-QT Relationships Play a Key Role in the Evaluation of Proarrhythmic Risk During Regulatory Review
J Clin Pharmacol 2008 48: 13. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

C. Shane McSwain, Ray Benza, Shelley Shapiro, Nicholas Hill, Robert Schilz, C. Gregory Elliott, Dianne L. Zwicke, Ronald J. Oudiz, James P. Staszewski, Carl P. Arneson, Michael Wade, David Zaccardelli, and Vallerie McLaughlin

Dose Proportionality of Treprostinil Sodium Administered by Continuous Subcutaneous and Intravenous Infusion
J Clin Pharmacol 2008 48: 19. [Abstract] [Full Text] [PDF]  

Barbara L. Powers, Deborah A. Wing, Denis Carr, Karine Ewert, and Mike Di Spirito

Pharmacokinetic Profiles of Controlled-Release Hydrogel Polymer Vaginal Inserts Containing Misoprostol
J Clin Pharmacol 2008 48: 26. [Abstract] [Full Text] [PDF]  

Quantitative Clinical Pharmacology:

John T. Mondick, Leonid Gibiansky, Marc R. Gastonguay, Jeffrey M. Skolnik, Michael Cole, Gareth J. Veal, Alan V. Boddy, Peter C. Adamson, and Jeffrey S. Barrett

Population Pharmacokinetic Investigation of Actinomycin-D in Children and Young Adults
J Clin Pharmacol 2008 48: 35. [Abstract] [Full Text] [PDF]  

Sukyung Woo, Wojciech Krzyzanski, Anne-Marie Duliege, Richard B. Stead, and William J. Jusko

Population Pharmacokinetics and Pharmacodynamics of Peptidic Erythropoiesis Receptor Agonist (ERA) in Healthy Volunteers
J Clin Pharmacol 2008 48: 43. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Nagy A. Farid, Christopher D. Payne, C. Steven Ernest, II, Y. Grace Li, Kenneth J. Winters, Daniel E. Salazar, and David S. Small

Prasugrel, a New Thienopyridine Antiplatelet Drug, Weakly Inhibits Cytochrome P450 2B6 in Humans
J Clin Pharmacol 2008 48: 53. [Abstract] [Full Text] [PDF]  

Vanitha J. Sekar, Sabrina Spinosa-Guzman, Els De Paepe, Martine De Pauw, Tony Vangeneugden, Eric Lefebvre, and Richard M. W. Hoetelmans

Darunavir/Ritonavir Pharmacokinetics Following Coadministration With Clarithromycin in Healthy Volunteers
J Clin Pharmacol 2008 48: 60. [Abstract] [Full Text] [PDF]  

Kyoung-Ah Kim, Pil-Whan Park, Kwang-Hyeon Liu, Kwon-Bok Kim, Heon-Jeong Lee, Jae-Gook Shin, and Ji-Young Park

Effect of Rifampin, an Inducer of CYP3A and P-glycoprotein, on the Pharmacokinetics of Risperidone
J Clin Pharmacol 2008 48: 66. [Abstract] [Full Text] [PDF]  

Ping Liu, Grover Foster, Robert R. LaBadie, Maria J. Gutierrez, and Amarnath Sharma

Pharmacokinetic Interaction Between Voriconazole and Efavirenz at Steady State in Healthy Male Subjects
J Clin Pharmacol 2008 48: 73. [Abstract] [Full Text] [PDF]  

Yan-Ling He, Monica Ligueros-Saylan, Gangadhar Sunkara, Ron Sabo, Charlie Zhao, Yibin Wang, Joelle Campestrini, Francoise Pommier, Kiran Dole, Alan Marion, William P. Dole, and Dan Howard

Vildagliptin, a Novel Dipeptidyl Peptidase IV Inhibitor, Has No Pharmacokinetic Interactions With the Antihypertensive Agents Amlodipine, Valsartan, and Ramipril in Healthy Subjects
J Clin Pharmacol 2008 48: 85. [Abstract] [Full Text] [PDF]  

Drug Metabolism:

Josephia R. Muindi, Michael D. Roth, Robert A. Wise, John E. Connett, George T. O'Connor, Joe W. Ramsdell, Neil W. Schluger, Marjorie Romkes, Robert A. Branch, Frank C. Sciurba for the FORTE Study Investigators

Pharmacokinetics and Metabolism of All-trans- and 13-cis-Retinoic Acid in Pulmonary Emphysema Patients
J Clin Pharmacol 2008 48: 96. [Abstract] [Full Text] [PDF]  

Pediatrics:

Kenneth T. Kim, Henry Milgrom, Y. Kellie Yoon, Arden L. Levy, Paul Matz, Michael J. Welch, Anthony Cahn, David A. Collins, Steven Kathman, Rashmi Mehta, Sheng-Fang Su, and Robert L. Kunka

Systemic Exposure and Urinary Cortisol Effects of Fluticasone Propionate Formulated With Hydrofluoroalkane in 4- to 11-Year-Olds With Asthma
J Clin Pharmacol 2008 48: 108. [Abstract] [Full Text] [PDF]  

Clinical Studies:

Francis M. Gengo, Lisa Rubin, Matthew Robson, Michelle Rainka, Michael F. Gengo, Donald E. Mager, and Vernice Bates

Effects of Ibuprofen on the Magnitude and Duration of Aspirin's Inhibition of Platelet Aggregation: Clinical Consequences in Stroke Prophylaxis
J Clin Pharmacol 2008 48: 117. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Charles S. Tressler and Gerald W. Bean

Letter to the Editor
J Clin Pharmacol 2008 48: 123. [Full Text] [PDF]  

R. J. González and G. Castañeda-Hernández

Authors' Response
J Clin Pharmacol 2008 48: 125. [Full Text] [PDF]  

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