Editorials:

Honghui Zhou

Biologics in the Pipeline: Large Molecules With High Hopes or Bigger Risks?
J Clin Pharmacol 2007 47: 550. [Full Text] [PDF]  

Biologics:

Mary Ann Mascelli, Honghui Zhou, Raymond Sweet, Jay Getsy, Hugh M. Davis, Martin Graham, and Darrell Abernethy

Molecular, Biologic, and Pharmacokinetic Properties of Monoclonal Antibodies: Impact of These Parameters on Early Clinical Development
J Clin Pharmacol 2007 47: 553. [Abstract] [Full Text] [PDF]  

Drug Metabolism/Transport:

Bradley L. Urquhart, Rommel G. Tirona, and Richard B. Kim

Nuclear Receptors and the Regulation of Drug-Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs
J Clin Pharmacol 2007 47: 566. [Abstract] [Full Text] [PDF]  

Dominique Levêque and François Jehl

Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids
J Clin Pharmacol 2007 47: 579. [Abstract] [Full Text] [PDF]  

White Paper:

Chandra S. Chaurasia, Markus Müller, Edward D. Bashaw, Eva Benfeldt, Jan Bolinder, Ross Bullock, Peter M. Bungay, Elizabeth C. M. DeLange, Hartmut Derendorf, William F. Elmquist, Margareta Hammarlund-Udenaes, Christian Joukhadar, Dean L. Kellogg, Jr, Craig E. Lunte, Carl Henrik Nordstrom, Hans Rollema, Ronald J. Sawchuk, Belinda W. Y. Cheung, Vinod P. Shah, Lars Stahle, Urban Ungerstedt, Devin F. Welty, and Helen Yeo

AAPS-FDA Workshop White Paper: Microdialysis Principles, Application, and Regulatory Perspectives
J Clin Pharmacol 2007 47: 589. [Full Text] [PDF]  

Drug Interactions:

Samir K. Gupta, Edward Sellers, Eugene Somoza, Luis Angles, Karen Kolz, and David L. Cutler

The Effect of Multiple Doses of Peginterferon alfa-2b on the Steady-State Pharmacokinetics of Methadone in Patients With Chronic Hepatitis C Undergoing Methadone Maintenance Therapy
J Clin Pharmacol 2007 47: 604. [Abstract] [Full Text] [PDF]  

Surya P. Ayalasomayajula, Sujata Vaidyanathan, Charisse Kemp, Pratapa Prasad, Alfred Balch, and William P. Dole

Effect of Clopidogrel on the Steady-State Pharmacokinetics of Fluvastatin
J Clin Pharmacol 2007 47: 613. [Abstract] [Full Text] [PDF]  

Jules I. Schwartz, Nancy G. B. Agrawal, Alan H. Hartford, Josee Cote, Thomas L. Hunt, Rene Verbesselt, Dane R. Eckols, and Keith M. Gottesdiener

The Effect of Etoricoxib on the Pharmacodynamics and Pharmacokinetics of Warfarin
J Clin Pharmacol 2007 47: 620. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

Gopal Krishna, James C. Kisicki, Steven Olsen, Dennis M. Grasela, and Zaiqi Wang

The Effect of Omeprazole on the Bioavailability and Safety of Garenoxacin in Healthy Volunteers
J Clin Pharmacol 2007 47: 628. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Yan-Ling He, Yibin Wang, Julie M. Bullock, Carolyn F. Deacon, Jens Juul Holst, Beth E. Dunning, Monica Ligueros-Saylan, and James E. Foley

Pharmacodynamics of Vildagliptin in Patients With Type 2 Diabetes During OGTT
J Clin Pharmacol 2007 47: 633. [Abstract] [Full Text] [PDF]  

Therapeutic Review:

Anna I. Kakafika, Dimitri P. Mikhailidis, Asterios Karagiannis, and Vasilios G. Athyros

The Role of Endocannabinoid System Blockade in the Treatment of the Metabolic Syndrome
J Clin Pharmacol 2007 47: 642. [Abstract] [Full Text] [PDF]  

Drug Delivery:

F. Wienforth, A. Landrock, C. Schindler, J. Siegert, and W. Kirch

Smart Textiles: A New Drug Delivery System for Symptomatic Treatment of a Common Cold
J Clin Pharmacol 2007 47: 653. [Abstract] [Full Text] [PDF]  

Brief Report/Pharmacokinetics:

Nassr Nassr, Gezim Lahu, Andreas Hünnemeyer, Oliver von Richter, Dietrich Knoerzer, Felix Reutter, Karl Zech, and Robert Hermann

Magnesium Hydroxide/Aluminium Hydroxide-Containing Antacid Does Not Affect the Pharmacokinetics of the Targeted Phosphodiesterase 4 Inhibitor Roflumilast
J Clin Pharmacol 2007 47: 660. [Full Text] [PDF]  

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