Biologics:

Markus Ries, Joe T. Clarke, Catharina Whybra, Atul Mehta, Kenneth S. Loveday, Roscoe O. Brady, Michael Beck, and Raphael Schiffmann

Enzyme Replacement in Fabry Disease: Pharmacokinetics and Pharmacodynamics of Agalsidase Alfa in Children and Adolescents
J Clin Pharmacol 2007 47: 1222. [Abstract] [Full Text] [PDF]  

Quantitative Clinical Pharmacology:

Alan Maloney, Mats O. Karlsson, and Ulrika S. H. Simonsson

Optimal Adaptive Design in Clinical Drug Development: A Simulation Example
J Clin Pharmacol 2007 47: 1231. [Abstract] [Full Text] [PDF] [Appendix]  

Petra M. Jauslin, Hanna E. Silber, Nicolas Frey, Ronald Gieschke, Ulrika S. H. Simonsson, Karin Jorga, and Mats O. Karlsson

An Integrated Glucose-Insulin Model to Describe Oral Glucose Tolerance Test Data in Type 2 Diabetics
J Clin Pharmacol 2007 47: 1244. [Abstract] [Full Text] [PDF] [Appendix]  

Pharmacokinetics:

Albert J. Azzaro, John Ziemniak, Eva Kemper, Bryan J. Campbell, and Chad VanDenBerg

Pharmacokinetics and Absolute Bioavailability of Selegiline Following Treatment of Healthy Subjects With the Selegiline Transdermal System (6 mg/24 h): A Comparison With Oral Selegiline Capsules
J Clin Pharmacol 2007 47: 1256. [Abstract] [Full Text] [PDF]  

Shaojun Shi, Jianhong Wu, Huating Chen, Hui Chen, Jun Wu, and Fandian Zeng

Single- and Multiple-Dose Pharmacokinetics of Pirfenidone, an Antifibrotic Agent, in Healthy Chinese Volunteers
J Clin Pharmacol 2007 47: 1268. [Abstract] [Full Text] [PDF]  

Paul L. M. van Giersbergen and Jasper Dingemanse

Influence of Food Intake on the Pharmacokinetics of Miglustat, an Inhibitor of Glucosylceramide Synthase
J Clin Pharmacol 2007 47: 1277. [Abstract] [Full Text] [PDF]  

Pharmacokinetics/Special Populations:

Samir K. Gupta, Bhavna Kantesaria, and Zaiqi Wang

Multiple-Dose Pharmacokinetics and Safety of Desloratadine in Subjects With Moderate Hepatic Impairment
J Clin Pharmacol 2007 47: 1283. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Adel H. Karara, Vladimir Hanes, Alberto Alonso, Pingping Ni, Nagaraju Poola, Rose Silang, Hartmut Blode, and Richard A. Preston

Pharmacokinetics and Pharmacodynamics of Drospirenone-Estradiol Combination Hormone Therapy Product Coadministered With Hydrochlorothiazide in Hypertensive Postmenopausal Women
J Clin Pharmacol 2007 47: 1292. [Abstract] [Full Text] [PDF]  

Pharmacodynamics:

Michel Guillaume, Finnuala Lonsdale, Christelle Darstein, Maria C. Jimenez, and Malcolm I. Mitchell

Hemodynamic Interaction Between a Daily Dosed Phosphodiesterase 5 Inhibitor, Tadalafil, and the -Adrenergic Blockers, Doxazosin and Tamsulosin, in Middle-Aged Healthy Male Subjects
J Clin Pharmacol 2007 47: 1303. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Daisuke Nakashima, Hirotaka Takama, Yuko Ogasawara, Tetsuyoshi Kawakami, Tsuyoshi Nishitoba, Sakuo Hoshi, Eiji Uchida, and Hideji Tanaka

Effect of Cinacalcet Hydrochloride, a New Calcimimetic Agent, on the Pharmacokinetics of Dextromethorphan: In Vitro and Clinical Studies
J Clin Pharmacol 2007 47: 1311. [Abstract] [Full Text] [PDF]  

Carla Washington, S. Y. Eddie Hou, Nicola C. Hughes, Corinne Campanella, and Bret Berner

Ciprofloxacin Prolonged-Release Tablets Do Not Affect Warfarin Pharmacokinetics and Pharmacodynamics
J Clin Pharmacol 2007 47: 1320. [Abstract] [Full Text] [PDF]  

Marc Bifano, Jing-He Yan, Robert A. Smith, Duxi Zhang, Dennis M. Grasela, and Frank LaCreta

Absence of a Pharmacokinetic Interaction Between Entecavir and Adefovir
J Clin Pharmacol 2007 47: 1327. [Abstract] [Full Text] [PDF]  

Clinical Studies:

Peter Brand, Thomas Meyer, Thomas Weuthen, Wolfgang Timmer, Erhard Berkel, Gudrun Wallenstein, and Gerhard Scheuch

Lung Deposition of Radiolabeled Tiotropium in Healthy Subjects and Patients With Chronic Obstructive Pulmonary Disease
J Clin Pharmacol 2007 47: 1335. [Abstract] [Full Text] [PDF]  

Brief Report/Drug Interactions:

Jules I. Schwartz, Nancy G. B. Agrawal, Uma A. Kher, Marina DeSmet, Paul F. Cavanaugh, Jr, Michel Guillaume, David L. Ebel, Shelia A. Merschman, and John A. Wagner

Lack of Effect of Antacids on Single-Dose Pharmacokinetics of Etoricoxib
J Clin Pharmacol 2007 47: 1342. [Full Text] [PDF]  

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