Forum:

J. Andrew Williams, Keith Johnson, Joseph Paulauskis, and Jack Cook

So Many Studies, Too Few Subjects: Establishing Functional Relevance of Genetic Polymorphisms on Pharmacokinetics
J Clin Pharmacol 2006 46: 258. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

Joanna Z. Peng, Federico Pulido, Sonja J. Kemmis Causemaker, Jianling Li, Alicia Lorenzo, Concepción Cepeda, Juan A. García Cabanillas, Barbara DaSilva, Scott C. Brun, and José Arribas

Pharmacokinetics of Lopinavir/Ritonavir in HIV/Hepatitis C Virus-Coinfected Subjects With Hepatic Impairment
J Clin Pharmacol 2006 46: 265. [Abstract] [Full Text] [PDF]  

Xiao-Jian Zhou, Deborah M. Lloyd, George C. Chao, and Nathaniel A. Brown

Absence of Food Effect on the Pharmacokinetics of Telbivudine Following Oral Administration in Healthy Subjects
J Clin Pharmacol 2006 46: 275. [Abstract] [Full Text] [PDF]  

Paul Frohna, Jianfeng Lu, Steve Eppler, Marta Hamilton, Julie Wolf, Ashok Rakhit, Jie Ling, Saraswati R. Kenkare-Mitra, and Bert L. Lum

Evaluation of the Absolute Oral Bioavailability and Bioequivalence of Erlotinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in a Randomized, Crossover Study in Healthy Subjects
J Clin Pharmacol 2006 46: 282. [Abstract] [Full Text] [PDF]  

Anup K. Majumdar, Laura Howard, Michael R. Goldberg, Lisa Hickey, Marvin Constanzer, Paul L. Rothenberg, Tami M. Crumley, Deborah Panebianco, Thomas E. Bradstreet, Arthur J. Bergman, Scott A. Waldman, Howard E. Greenberg, Kathleen Butler, A. Knops, Inge De Lepeleire, Nicole Michiels, and Kevin J. Petty

Pharmacokinetics of Aprepitant After Single and Multiple Oral Doses in Healthy Volunteers
J Clin Pharmacol 2006 46: 291. [Abstract] [Full Text] [PDF]  

Nishit B. Modi, Mark J. Dresser, Mary Simon, Denise Lin, Dhaval Desai, and Suneel Gupta

Single- and Multiple-Dose Pharmacokinetics of Dapoxetine Hydrochloride, a Novel Agent for the Treatment of Premature Ejaculation
J Clin Pharmacol 2006 46: 301. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Jean-Francois Marier, Rudolf Guilbaud, Siva Rama Prasad Kambhampati, Philip Mathew, James Moberly, James Lee, and Daniel E. Salazar

The Effect of AST-120 on the Single-Dose Pharmacokinetics of Losartan and Losartan Acid (E-3174) in Healthy Subjects
J Clin Pharmacol 2006 46: 310. [Abstract] [Full Text] [PDF]  

Arthur J. Bergman, Joanne Burke, Patrick Larson, Amy O. Johnson-Levonas, Larisa Reyderman, Paul Statkevich, Teddy Kosoglou, Howard E. Greenberg, Walter K. Kraft, Glenn Frick, Gail Murphy, Keith Gottesdiener, and John F. Paolini

Effects of Ezetimibe on Cyclosporine Pharmacokinetics in Healthy Subjects
J Clin Pharmacol 2006 46: 321. [Abstract] [Full Text] [PDF]  

Arthur J. Bergman, Joanne Burke, Patrick Larson, Amy O. Johnson-Levonas, Larisa Reyderman, Paul Statkevich, Stephen E. Maxwell, Teddy Kosoglou, Gail Murphy, Keith Gottesdiener, Richard Robson, and John F. Paolini

Interaction of Single-Dose Ezetimibe and Steady-State Cyclosporine in Renal Transplant Patients
J Clin Pharmacol 2006 46: 328. [Abstract] [Full Text] [PDF]  

Drug Metabolism:

Miki Nakajima, Masahiro Itoh, Hiroyuki Yamanaka, Tatsuki Fukami, Shogo Tokudome, Yasuhiko Yamamoto, Hiroshi Yamamoto, and Tsuyoshi Yokoi

Isoflavones Inhibit Nicotine C-Oxidation Catalyzed by Human CYP2A6
J Clin Pharmacol 2006 46: 337. [Abstract] [Full Text] [PDF]  

Yanhua Zhang, Myong-Jin Kim, Joseph S. Bertino, Jr, Anne N. Nafziger, and Edward M. Sellers

Use of Omeprazole as a CYP3A Probe Drug: Effect of Sex and Menstrual Cycle Phase on CYP3A Activity in Healthy Caucasian Adults
J Clin Pharmacol 2006 46: 345. [Abstract] [Full Text] [PDF]  

Review:

Harry V. Gelboin and Kristopher Krausz

Monoclonal Antibodies and Multifunctional Cytochrome P450: Drug Metabolism as Paradigm
J Clin Pharmacol 2006 46: 353. [Abstract] [Full Text] [PDF]  

Brief Reports/Pharmacogenomics:

Pengfei Song, Jatinder K. Lamba, Lijun Zhang, Erin Schuetz, Nikhil Shukla, Bernd Meibohm, and Charles R. Yates

G2677T and C3435T Genotype and Haplotype Are Associated With Hepatic ABCB1 (MDR1) Expression
J Clin Pharmacol 2006 46: 373. [Full Text] [PDF]  

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