Therapeutic Review:

Marta Boffito, Desmond Maitland, and Anton Pozniak

Practical Perspectives on the Use of Tipranavir in Combination With Other Medications: Lessons Learned From Pharmacokinetic Studies
J Clin Pharmacol 2006 46: 130. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

Aziz Karim, Dwain Tolbert, and Charlie Cao

Disposition Kinetics and Tolerance of Escalating Single Doses of Ramelteon, a High-Affinity MT₁ and MT₂ Melatonin Receptor Agonist Indicated for Treatment of Insomnia
J Clin Pharmacol 2006 46: 140. [Abstract] [Full Text] [PDF]  

John M. Kovarik, Robert L. Schmouder, Stefan Hartmann, Gilles-Jacques Riviere, Franck Picard, Brigitta Voss, Markus Weiss, Frank Wagner, and Hartmut H.-J. Schmidt

Fingolimod (FTY720) in Severe Hepatic Impairment: Pharmacokinetics and Relationship to Markers of Liver Function
J Clin Pharmacol 2006 46: 149. [Abstract] [Full Text] [PDF]  

Ophelia Q. P. Yin, Brian Tomlinson, and Moses S. S. Chow

Variability in Renal Clearance of Substrates for Renal Transporters in Chinese Subjects
J Clin Pharmacol 2006 46: 157. [Abstract] [Full Text] [PDF]  

John S. Markowitz, C. Lindsay DeVane, Robert J. Malcolm, Holly A. Gefroh, Jun-Sheng Wang, Hao-Jie Zhu, and Jennifer L. Donovan

Pharmacokinetics of Olanzapine After Single-Dose Oral Administration of Standard Tablet Versus Normal and Sublingual Administration of an Orally Disintegrating Tablet in Normal Volunteers
J Clin Pharmacol 2006 46: 164. [Abstract] [Full Text] [PDF]  

Suzanne K. Swan, Harry Alcorn, Jr, Anthony Rodgers, Carolyn M. Hustad, Karen E. Ramsey, Susan Woll, and Franck Skobieranda

Pharmacokinetic Profile of Rizatriptan 10-mg Tablet and 10-mg Orally Disintegrating Tablet Administered With or Without Water in Healthy Subjects: An Open-Label, Randomized, Single-Dose, 3-Period Crossover Study
J Clin Pharmacol 2006 46: 172. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Domenic A. Ciraulo, Robert J. Hitzemann, Eugene Somoza, Clifford M. Knapp, John Rotrosen, Ofra Sarid-Segal, Ann Marie Ciraulo, David J. Greenblatt, and C. Nora Chiang

Pharmacokinetics and Pharmacodynamics of Multiple Sublingual Buprenorphine Tablets in Dose-Escalation Trials
J Clin Pharmacol 2006 46: 179. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Jing-He Yan, Maria R. Marino, Robert A. Smith, Vanaja Kanamaluru, Edward M. O'Mara, and Dennis M. Grasela

The Effect of Ravuconazole on the Pharmacokinetics of Nelfinavir in Healthy Male Volunteers
J Clin Pharmacol 2006 46: 193. [Abstract] [Full Text] [PDF]  

Drug Metabolism:

Bill Gurley, Martha A. Hubbard, D. Keith Williams, John Thaden, Yudong Tong, W. Brooks Gentry, Philip Breen, Danielle J. Carrier, and Shreekar Cheboyina

Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin
J Clin Pharmacol 2006 46: 201. [Abstract] [Full Text] [PDF]  

David J. Greenblatt, Lisa L. von Moltke, Yan Luo, Elke S. Perloff, Kelly A. Horan, Allison Bruce, Robyn C. Reynolds, Jerold S. Harmatz, Bharathi Avula, Ikhlas A. Khan, and Peter Goldman

Ginkgo biloba Does Not Alter Clearance of Flurbiprofen, a Cytochrome P450-2C9 Substrate
J Clin Pharmacol 2006 46: 214. [Abstract] [Full Text] [PDF]  

Barbara J. Brennan, Angus B. Brown, Stanley J. Kolis, Olga Rutman, Calvin Gooden, and Brian E. Davies

Effect of R667, a Novel Emphysema Agent, on the Pharmacokinetics of Midazolam in Healthy Men
J Clin Pharmacol 2006 46: 222. [Abstract] [Full Text] [PDF]  

Lois S. Lee, Joseph S. Bertino, Jr, and Anne N. Nafziger

Limited Sampling Models for Oral Midazolam: Midazolam Plasma Concentrations, Not the Ratio of 1-Hydroxymidazolam to Midazolam Plasma Concentrations, Accurately Predicts AUC as a Biomarker of CYP3A Activity
J Clin Pharmacol 2006 46: 229. [Abstract] [Full Text] [PDF]  

Adverse Events:

Keith Tan, Nigel Brayshaw, Konrad Tomaszewski, Peter Troke, and Nolan Wood

Investigation of the Potential Relationships Between Plasma Voriconazole Concentrations and Visual Adverse Events or Liver Function Test Abnormalities
J Clin Pharmacol 2006 46: 235. [Abstract] [Full Text] [PDF] [Supplementary Data]  

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