Therapeutic Review and Commentary:

Panagiotis A. Konstantinopoulos and David F. Lehmann

The Cardiovascular Toxicity of Selective and Nonselective Cyclooxygenase Inhibitors: Comparisons, Contrasts, and Aspirin Confounding
J Clin Pharmacol 2005 45: 742. [Abstract] [Full Text] [PDF]  

Therapeutic Review:

Tanya Doan and Elena Massarotti

Rheumatoid Arthritis: An Overview of New and Emerging Therapies
J Clin Pharmacol 2005 45: 751. [Abstract] [Full Text] [PDF]  

Clinical Studies:

Milan Zdravkovic, Matthias Kruse, Karl Ludwig Rost, Judi Møss, Andrei Kecskes, and Thomas Dyrberg

The Effects of NN414, a SUR1/Kir6.2 Selective Potassium Channel Opener, in Healthy Male Subjects
J Clin Pharmacol 2005 45: 763. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Roger D. Toothaker, Alfred E. Corey, Suzanne N. Valentine, Jeff R. Agnew, Nikhil Parekh, Werner Moehrke, Gary A. Thompson, and James H. Powell

Influence of Coadministration on the Pharmacokinetics of Azimilide Dihydrochloride and Digoxin
J Clin Pharmacol 2005 45: 773. [Abstract] [Full Text] [PDF]  

Klemens Budde, Gustav Lehne, Michael Winkler, Lutz Renders, Arno Lison, Lutz Fritsche, Jean-Paul Soulillou, Per Fauchald, Hans-Hellmut Neumayer, Jaques Dantal RADW 102 Renal Transplant Study Group

Influence of Everolimus on Steady-State Pharmacokinetics of Cyclosporine in Maintenance Renal Transplant Patients
J Clin Pharmacol 2005 45: 781. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

Chee M. Ng, Rene Bruno, Dan Combs, and Brian Davies

Population Pharmacokinetics of Rituximab (Anti-CD20 Monoclonal Antibody) in Rheumatoid Arthritis Patients During a Phase II Clinical Trial
J Clin Pharmacol 2005 45: 792. [Abstract] [Full Text] [PDF]  

Hisham Abdallah and Markus Jerling

Effect of Hepatic Impairment on the Multiple-Dose Pharmacokinetics of Ranolazine Sustained-Release Tablets
J Clin Pharmacol 2005 45: 802. [Abstract] [Full Text] [PDF]  

William R. Ravis, Susan Reid, Domenic A. Sica, and Dwain S. Tolbert

Pharmacokinetics of Eplerenone After Single and Multiple Dosing in Subjects With and Without Renal Impairment
J Clin Pharmacol 2005 45: 810. [Abstract] [Full Text] [PDF]  

Edgar L. Schuck, Maria Grant, and Hartmut Derendorf

Effect of Simulated Microgravity on the Disposition and Tissue Penetration of Ciprofloxacin in Healthy Volunteers
J Clin Pharmacol 2005 45: 822. [Abstract] [Full Text] [PDF]  

Robert E. Ariano, Sheryl A. Zelenitsky, Anna Nyhlén, and Daniel S. Sitar

An Evaluation of an Optimal Sampling Strategy for Meropenem in Febrile Neutropenics
J Clin Pharmacol 2005 45: 832. [Abstract] [Full Text] [PDF]  

Beatrice Astruc, Peter Marbach, Hakim Bouterfa, Caroline Denot, Mitra Safari, Alessandra Vitaliti, and Michael Sheppard

Long-Acting Octreotide and Prolonged-Release Lanreotide Formulations Have Different Pharmacokinetic Profiles
J Clin Pharmacol 2005 45: 836. [Abstract] [Full Text] [PDF]  

Hartmut Derendorf, Cam P. VanderMaelen, Rolf-Stefan Brickl, Tom R. MacGregor, and Wolfgang Eisert

Dipyridamole Bioavailability in Subjects With Reduced Gastric Acidity
J Clin Pharmacol 2005 45: 845. [Abstract] [Full Text] [PDF]  

Brief Reports/Pharmacodynamics:

Ronan P. Kelly, Kwee Poo Yeo, Choo-Hua Teng, Brian P. Smith, Stephen Lowe, Danny Soon, Holly A. Read, and Stephen D. Wise

Hemodynamic Effects of Acute Administration of Atomoxetine and Methylphenidate
J Clin Pharmacol 2005 45: 851. [Full Text] [PDF]  

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