Therapeutic Review:

Honghui Zhou

Clinical Pharmacokinetics of Etanercept: A Fully Humanized Soluble Recombinant Tumor Necrosis Factor Receptor Fusion Protein
J Clin Pharmacol 2005 45: 490. [Abstract] [Full Text] [PDF]  

Drug Development:

Olaf Holz, Ruth Tal-Singer, Frank Kanniess, Kathy J. Simpson, Anthony Gibson, Rupert S. J. Vessey, Stanislawa Janicki, Helgo Magnussen, Rudolf A. Jörres, and Kai Richter

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development
J Clin Pharmacol 2005 45: 498. [Abstract] [Full Text] [PDF]  

J. A. Wagner, P. J. Larson, S. Weiss, J. L. Miller, T. W. Doebber, M. S. Wu, D. E. Moller, and K. M. Gottesdiener

Individual and Combined Effects of Peroxisome Proliferator-Activated Receptor and Agonists, Fenofibrate and Rosiglitazone, on Biomarkers of Lipid and Glucose Metabolism in Healthy Nondiabetic Volunteers
J Clin Pharmacol 2005 45: 504. [Abstract] [Full Text] [PDF]  

Drug Interactions:

J. M. Kovarik, D. Beyer, M. N. Bizot, Q. Jiang, M. Shenouda, and R. L. Schmouder

Blood Concentrations of Everolimus Are Markedly Increased by Ketoconazole
J Clin Pharmacol 2005 45: 514. [Abstract] [Full Text] [PDF]  

Caiping Yao, Arash Raoufinia, Michael Gold, Jeffrey S. Nye, Steven Ramael, Mukund Padmanabhan, Yolande Walschap, Tom Verhaeghe, and Qinying Zhao

Steady-State Pharmacokinetics of Galantamine Are Not Affected by Addition of Memantine in Healthy Subjects
J Clin Pharmacol 2005 45: 519. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Karthik Venkatakrishnan, Kerry E. Culm, Bruce L. Ehrenberg, Jerold S. Harmatz, Kathleen E. Corbett, Joseph C. Fleishaker, and David J. Greenblatt

Kinetics and Dynamics of Intravenous Adinazolam, N-Desmethyl Adinazolam, and Alprazolam in Healthy Volunteers
J Clin Pharmacol 2005 45: 529. [Abstract] [Full Text] [PDF]  

Chun-Su Yuan, Harold Doshan, Martha R. Charney, Michael O'Connor, Theodore Karrison, S. A. Maleckar, Robert J. Israel, and Jonathan Moss

Tolerability, Gut Effects, and Pharmacokinetics of Methylnaltrexone Following Repeated Intravenous Administration in Humans
J Clin Pharmacol 2005 45: 538. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

Vijay Vashi, Stephen Harris, Ahmed El-Tahtawy, Danlin Wu, and Alessandra Cipriano

Clinical Pharmacology and Pharmacokinetics of Once-Daily Hydromorphone Hydrochloride Extended-Release Capsules
J Clin Pharmacol 2005 45: 547. [Abstract] [Full Text] [PDF]  

Joachim Stangier, Bengt I. Eriksson, Ola E. Dahl, Lennart Ahnfelt, Gerhard Nehmiz, Hildegard Stähle, Karin Rathgen, and Robbyna Svärd

Pharmacokinetic Profile of the Oral Direct Thrombin Inhibitor Dabigatran Etexilate in Healthy Volunteers and Patients Undergoing Total Hip Replacement
J Clin Pharmacol 2005 45: 555. [Abstract] [Full Text] [PDF]  

Ping Liu, Markus Müller, Maria Grant, Bernd Obermann, and Hartmut Derendorf

Tissue Penetration of Cefpodoxime and Cefixime in Healthy Subjects
J Clin Pharmacol 2005 45: 564. [Abstract] [Full Text] [PDF]  

Erich Blase, Kristin Taylor, Hong-ye Gao, Matthew Wintle, and Mark Fineman

Pharmacokinetics of an Oral Drug (Acetaminophen) Administered at Various Times in Relation to Subcutaneous Injection of Exenatide (Exendin-4) in Healthy Subjects
J Clin Pharmacol 2005 45: 570. [Abstract] [Full Text] [PDF]  

Yue Huang, Susanne Ostrowitzki, George Hill, Mercidita Navarro, Nancy Berger, Paul Kopeck, Cheng I. Mau, Tom Alfredson, and Ritu Lal

Single- and Multiple-Dose Pharmacokinetics of Levovirin Valinate Hydrochloride (R1518) in Healthy Volunteers
J Clin Pharmacol 2005 45: 578. [Abstract] [Full Text] [PDF]  

Thomas L. Hunt, Susan C. Gallagher, Michael T. Cullen, Jr, and Ajit K. Shah

Evaluation of Safety and Pharmacokinetics of Consecutive Multiple-Day Dosing of Palonosetron in Healthy Subjects
J Clin Pharmacol 2005 45: 589. [Abstract] [Full Text] [PDF]  

Clinical Studies:

Guido Marcucci, Lewis Silverman, Mark Eller, Linda Lintz, and C. L. Beach

Bioavailability of Azacitidine Subcutaneous Versus Intravenous in Patients With the Myelodysplastic Syndromes
J Clin Pharmacol 2005 45: 597. [Abstract] [Full Text] [PDF]  

Errata:

Erratum
J Clin Pharmacol 2005 45: 603. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.