Therapeutic Review:

Francis E. Lotrich and Bruce G. Pollock

Aging and Clinical Pharmacology: Implications for Antidepressants
J Clin Pharmacol 2005 45: 1106. [Abstract] [Full Text] [PDF]  

Drug Development:

Camilla Buoen, Ole J. Bjerrum, and Mikael S. Thomsen

How First-Time-in-Human Studies Are Being Performed: A Survey of Phase I Dose-Escalation Trials in Healthy Volunteers Published Between 1995 and 2004
J Clin Pharmacol 2005 45: 1123. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

Michael L. Christensen, Bernd Meibohm, Edmund V. Capparelli, Pedro Velasquez-Mieyer, George A. Burghen, and William V. Tamborlane

Single- and Multiple-Dose Pharmacokinetics of Pioglitazone in Adolescents With Type 2 Diabetes
J Clin Pharmacol 2005 45: 1137. [Abstract] [Full Text] [PDF]  

Mary F. Hebert, Helen E. Smith, Thomas C. Marbury, Suzanne K. Swan, William B. Smith, Robert W. Townsend, Donald Buell, James Keirns, and Ihor Bekersky

Pharmacokinetics of Micafungin in Healthy Volunteers, Volunteers With Moderate Liver Disease, and Volunteers With Renal Dysfunction
J Clin Pharmacol 2005 45: 1145. [Abstract] [Full Text] [PDF]  

Gary D. Stoner, Christine Sardo, Glen Apseloff, Dan Mullet, Wayne Wargo, Vickie Pound, Alpana Singh, James Sanders, Robeena Aziz, Bruce Casto, and XiaoLi Sun

Pharmacokinetics of Anthocyanins and Ellagic Acid in Healthy Volunteers Fed Freeze-Dried Black Raspberries Daily for 7 Days
J Clin Pharmacol 2005 45: 1153. [Abstract] [Full Text] [PDF]  

Clinical Studies:

Laura P. James, Pippa M. Simpson, Henry C. Farrar, Gregory L. Kearns, Gary S. Wasserman, Jeffrey L. Blumer, Michael D. Reed, Janice E. Sullivan, Jack A. Hinson, and The Pediatric Pharmacology Research Unit Network

Cytokines and Toxicity in Acetaminophen Overdose
J Clin Pharmacol 2005 45: 1165. [Abstract] [Full Text] [PDF]  

J. Jermany, J. Branson, R. Schmouder, M. Guillaume, and C. Rordorf

Lumiracoxib Does Not Affect the Ex Vivo Antiplatelet Aggregation Activity of Low-Dose Aspirin in Healthy Subjects
J Clin Pharmacol 2005 45: 1172. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Majid Vakily, Fouad Amer, Michael J. Kukulka, and Nupun Andhivarothai

Coadministration of Lansoprazole and Naproxen Does Not Affect the Pharmacokinetic Profile of Methotrexate in Adult Patients With Rheumatoid Arthritis
J Clin Pharmacol 2005 45: 1179. [Abstract] [Full Text] [PDF]  

Drug Metabolism:

Evan D. Kharasch, Alysa Walker, Christine Hoffer, and Pamela Sheffels

Sensitivity of Intravenous and Oral Alfentanil and Pupillary Miosis as Minimally Invasive and Noninvasive Probes for Hepatic and First-Pass CYP3A Activity
J Clin Pharmacol 2005 45: 1187. [Abstract] [Full Text] [PDF]  

Methods:

Nenad Sarapa, Poe-Hirr Hsyu, Graham Lappin, and Ronald Colin Garner

The Application of Accelerator Mass Spectrometry to Absolute Bioavailability Studies in Humans: Simultaneous Administration of an Intravenous Microdose of ¹⁴C-Nelfinavir Mesylate Solution and Oral Nelfinavir to Healthy Volunteers
J Clin Pharmacol 2005 45: 1198. [Abstract] [Full Text] [PDF]  

Errata:

Erratum
J Clin Pharmacol 2005 45: 1206. [Full Text] [PDF]  

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