Special Review in Drug Metabolism:

Joseph D. Ma, Anne N. Nafziger, and Joseph S. Bertino, Jr.

Genetic Polymorphisms of Cytochrome P450 Enzymes and the Effect on Interindividual, Pharmacokinetic Variability in Extensive Metabolizers
J Clin Pharmacol 2004 44: 447. [Abstract] [Full Text] [PDF]  

Methods:

Steven G. Terra, Robert A. Blum, Greg C. Wei, Robert A. Lew, Andres G. Digenio, Iris Rajman, and David J. Kazierad

Evaluation of Methods for Improving Precision of Blood Pressure Measurements in Phase I Clinical Trials
J Clin Pharmacol 2004 44: 457. [Abstract] [Full Text] [PDF]  

Gary J. Noel, Daniel B. Goodman, Shuchean Chien, Bhavna Solanki, Mukund Padmanabhan, and Jaya Natarajan

Measuring the Effects of Supratherapeutic Doses of Levofloxacin on Healthy Volunteers Using Four Methods of QT Correction and Periodic and Continuous ECG Recordings
J Clin Pharmacol 2004 44: 464. [Abstract] [Full Text] [PDF]  

Clinical Trials:

Robert J. Noveck and Richard C. Hubbard

Parecoxib Sodium, an Injectable COX-2-Specific Inhibitor, Does Not Affect Unfractionated Heparin-Regulated Blood Coagulation Parameters
J Clin Pharmacol 2004 44: 474. [Abstract] [Full Text] [PDF]  

Molecular Pharmacology:

Toshihiko Hirano, Kenji Onda, Tsugutoshi Toma, Masaaki Miyaoka, Fuminori Moriyasu, and Kitaro Oka

MDR1 mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Ulcerative Colitis in Relation to Glucocorticoid Administration
J Clin Pharmacol 2004 44: 481. [Abstract] [Full Text] [PDF]  

Pediatrics:

Elizabeth Migoya, Gregory L. Kearns, Alan Hartford, Jamie Zhao, Janet van Adelsberg, Carol A. Tozzi, Barbara Knorr, and Paul Deutsch

Pharmacokinetics of Montelukast in Asthmatic Patients 6 to 24 Months Old
J Clin Pharmacol 2004 44: 487. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Shekman L. Wong, David T.-W. Lau, Sharon A. Baughman, Nick Fotheringham, Dora Menchaca, and Marc B. Garnick

Pharmacokinetics and Pharmacodynamics of a Novel Depot Formulation of Abarelix, a Gonadotropin-Releasing Hormone (GnRH) Antagonist, in Healthy Men Ages 50 to 75
J Clin Pharmacol 2004 44: 495. [Abstract] [Full Text] [PDF]  

Michael Wade, F. Jo Baker, Robert Roscigno, Wayne DellaMaestra, Carl P. Arneson, Thomas L. Hunt, and Allen A. Lai

Pharmacokinetics of Treprostinil Sodium Administered by 28-Day Chronic Continuous Subcutaneous Infusion
J Clin Pharmacol 2004 44: 503. [Abstract] [Full Text] [PDF]  

Robert Hermann, Mathias Locher, Marianne Siebert-Weigel, Nicole LaVallee, Hartmut Derendorf, and Günther Hochhaus

Intranasal Loteprednol Etabonate in Healthy Male Subjects: Pharmacokinetics and Effects on Endogenous Cortisol
J Clin Pharmacol 2004 44: 510. [Abstract] [Full Text] [PDF]  

Randall Stoltz, Jong-Chol Cyong, Ajit Shah, and Simona Parisi

Pharmacokinetic and Safety Evaluation of Palonosetron, a 5-Hydroxytryptamine-3 Receptor Antagonist, in U.S. and Japanese Healthy Subjects
J Clin Pharmacol 2004 44: 520. [Abstract] [Full Text] [PDF]  

John M. Kovarik, Robert Schmouder, Denise Barilla, Gilles-Jacques Riviere, Yibin Wang, and Thomas Hunt

Multiple-Dose FTY720: Tolerability, Pharmacokinetics, and Lymphocyte Responses in Healthy Subjects
J Clin Pharmacol 2004 44: 532. [Abstract] [Full Text] [PDF]  

Herbal Medicine:

Norio Yasui-Furukori, Hanako Furukori, Ayako Kaneda, Sunao Kaneko, and Tomonori Tateishi

The Effects of Ginkgo biloba Extracts on the Pharmacokinetics and Pharmacodynamics of Donepezil
J Clin Pharmacol 2004 44: 538. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Honghui Zhou, Alain Patat, Virginia Parks, Mary Buckwalter, Deborah Metzger, and Joan Korth-Bradley

Absence of a Pharmacokinetic Interaction between Etanercept and Warfarin
J Clin Pharmacol 2004 44: 543. [Abstract] [Full Text] [PDF]  

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