Therapeutic Review:

Arif Asif, David L. Epstein, and Murray Epstein

Dopamine-1 Receptor Agonist: Renal Effects and Its Potential Role in the Management of Radiocontrast-Induced Nephropathy
J Clin Pharmacol 2004 44: 1342. [Abstract] [Full Text] [PDF]  

Geriatrics:

Robert R. Bies, Yan Feng, Francis E. Lotrich, Margaret A. Kirshner, Steven Roose, David J. Kupfer, and Bruce G. Pollock

Utility of Sparse Concentration Sampling for Citalopram in Elderly Clinical Trial Subjects
J Clin Pharmacol 2004 44: 1352. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Bernard Beer, Jill Stark, Philip Krieter, Pal Czobor, Gary Beer, Arnold Lippa, and Phil Skolnick

DOV 216,303, a "Triple" Reuptake Inhibitor: Safety, Tolerability, and Pharmacokinetic Profile
J Clin Pharmacol 2004 44: 1360. [Abstract] [Full Text] [PDF]  

Youssef Hijazi, Horst Welker, Albert E. Dorr, Jian-Ping Tang, Roger Blain, Louis M. Renzetti, and Richat Abbas

Pharmacokinetics, Safety, and Tolerability of R411, a Dual 4ß1-4ß7 Integrin Antagonist After Oral Administration at Single and Multiple Once-Daily Ascending Doses in Healthy Volunteers
J Clin Pharmacol 2004 44: 1368. [Abstract] [Full Text] [PDF]  

Iolanda Cirillo, Nancy E. Martin, Barbara Brennan, and Jeffrey S. Barrett

The Effect of Food on the Pharmacokinetics of a Dual Angiotensin-Converting Enzyme/Neutral Endopeptidase Inhibitor, M100240
J Clin Pharmacol 2004 44: 1379. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Chih-Chiang Chiu, Hsien-Yuan Lane, Ming-Chyi Huang, Hui-Ching Liu, Michael W. Jann, Yuen-Yi Hon, Wen-Ho Chang, and Mong-Liang Lu

Dose-Dependent Alternations in the Pharmacokinetics of Olanzapine During Coadministration of Fluvoxamine in Patients With Schizophrenia
J Clin Pharmacol 2004 44: 1385. [Abstract] [Full Text] [PDF]  

Karl Madaras-Kelly, Patricia Michas, Molly George, Matthew P. May, and Adeboye Adejare

A Randomized Crossover Study Investigating the Influence of Ranitidine or Omeprazole on the Pharmacokinetics of Cephalexin Monohydrate
J Clin Pharmacol 2004 44: 1391. [Abstract] [Full Text] [PDF]  

Methods:

Mahmut Özdemir, Kim H. Crewe, Geoffrey T. Tucker, and Amin Rostami-Hodjegan

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH
J Clin Pharmacol 2004 44: 1398. [Abstract] [Full Text] [PDF]  

Drug Metabolism:

Louis R. Cantilena, Aspandiar G. Katki, Raymond W. Klecker, and Jerry M. Collins

Metabolism by N-Acetyltransferase 1 In Vitro and in Healthy Volunteers: A Prototype for Targeted Inhibition
J Clin Pharmacol 2004 44: 1405. [Abstract] [Full Text] [PDF]  

Ophelia Q. P. Yin, Xiaojin Shi, Brian Tomlinson, and Moses S. S. Chow

Interindividual and Intraindividual Variability of the Urinary 6ß-Hydroxycortisol/Cortisol Ratio in Chinese Subjects: Implications of Its Use for Evaluating CYP3A Activity
J Clin Pharmacol 2004 44: 1412. [Abstract] [Full Text] [PDF]  

Analgesia:

Raymond A. Dionne, Duncan Haynes, Jaime S. Brahim, Janet S. Rowan, and Pol-Henri Guivarc'h

Analgesic Effect of Sustained-Release Flurbiprofen Administered at the Site of Tissue Injury in the Oral Surgery Model
J Clin Pharmacol 2004 44: 1418. [Abstract] [Full Text] [PDF]  

Brief Reports/Analgesia:

Indu Taneja, Stephen Bruehl, and David Robertson

Effect of Modafinil on Acute Pain: A Randomized Double-Blind Crossover Study
J Clin Pharmacol 2004 44: 1425. [Full Text] [PDF]  

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