Articles:

NR Cutler and JJ Sramek

Investigator perspective on MTD: practical application of an MTD definition--has it accelerated development?
J Clin Pharmacol 2000 40: 1184. [PDF]  

DJ Greenblatt

Academic perspectives on the MTD: pharmacodynamic end points: maximizing the value of MTD studies
J Clin Pharmacol 2000 40: 1188. [PDF]  

P Chaikin

Industry perspectives on the MTD: growing acceptance in clinical development programs
J Clin Pharmacol 2000 40: 1191. [PDF]  

J Collins

Regulatory perspective on the MTD: is there a role for surrogate markers?
J Clin Pharmacol 2000 40: 1199. [PDF]  

R Spector and ES Vesell

The pursuit of clinical truth: role of epidemiology/observation studies
J Clin Pharmacol 2000 40: 1205. [Abstract] [PDF]  

S Rohatagi, F Calic, N Harding, ML Ozoux, JP Bouriot, S Kirkesseli, L DeLeij, and BK Jensen

Pharmacokinetics, pharmacodynamics, and safety of inhaled cyclosporin A (ADI628) after single and repeated administration in healthy male and female subjects and asthmatic patients
J Clin Pharmacol 2000 40: 1211. [Abstract] [PDF]  

MB Affrime, F Cuss, D Padhi, M Wirth, S Pai, RP Clement, J Lim, B Kantesaria, K Alton, and MN Cayen

Bioavailability and metabolism of mometasone furoate following administration by metered-dose and dry-powder inhalers in healthy human volunteers
J Clin Pharmacol 2000 40: 1227. [Abstract] [PDF]  

HJ Heller, LG Greer, SD Haynes, Poindexter, JR, and CY Pak

Pharmacokinetic and pharmacodynamic comparison of two calcium supplements in postmenopausal women
J Clin Pharmacol 2000 40: 1237. [Abstract] [PDF]  

PN Zannikos, S Rohatagi, BK Jensen, SL DePhillips, D Massignon, F Calic, M Sibille, and S Kirkesseli

Pharmacokinetics, pharmacodynamics, and safety of a platelet GPIIb/IIIa antagonist, RGD891, following intravenous administration in healthy male volunteers
J Clin Pharmacol 2000 40: 1245. [Abstract] [PDF]  

D Wang, R Miller, J Zheng, and C Hu

Comparative population pharmacokinetic-pharmacodynamic analysis for piroxicam-beta-cyclodextrin and piroxicam
J Clin Pharmacol 2000 40: 1257. [Abstract] [PDF]  

A Vilella, R Dal-Re, D Simo, P Garcia-Corbeira, P Diego, and JM Bayas

Reactogenicity profile of tetanus-diphtheria (adult-type) vaccine: results of a naturalistic study performed at an adult vaccination center
J Clin Pharmacol 2000 40: 1267. [Abstract] [PDF]  

T Prueksaritanont, JM Vega, JD Rogers, K Gagliano, HE Greenberg, L Gillen, MJ Brucker, D McLoughlin, PH Wong, and SA Waldman

Simvastatin does not affect CYP3A activity, quantified by the erythromycin breath test and oral midazolam pharmacokinetics, in healthy male subjects
J Clin Pharmacol 2000 40: 1274. [Abstract] [PDF]  

RA Di Cicco, A Allen, A Carr, S Fowles, DK Jorkasky, and MI Freed

Rosiglitazone does not alter the pharmacokinetics of metformin
J Clin Pharmacol 2000 40: 1280. [Abstract] [PDF]  

MK Erjavec, BA Coda, Q Nguyen, G Donaldson, L Risler, and DD Shen

Morphine-fluoxetine interactions in healthy volunteers: analgesia and side effects
J Clin Pharmacol 2000 40: 1286. [Abstract] [PDF]  

SA Allen

Effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia
J Clin Pharmacol 2000 40: 1296. [Abstract] [PDF]  

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