Articles:

Metoprolol CR/ZOK. Proceedings of a workshop. Eze, France, September 7-9, 1989
J Clin Pharmacol 1990 30: S1 -S138. [PDF]  

A Sandberg, B Abrahamsson, CG Regardh, I Wieselgren, and R Bergstrand

Pharmacokinetic and biopharmaceutic aspects of once daily treatment with metoprolol CR/ZOK: a review article
J Clin Pharmacol 1990 30: S2 -S16. [Abstract] [PDF]  

P Lucker, G Moore, I Wieselgren, B Olofsson, and R Bergstrand

Pharmacokinetic and pharmacodynamic comparison of metoprolol CR/ZOK once daily with conventional tablets once daily and in divided doses
J Clin Pharmacol 1990 30: S17 -S27. [Abstract] [PDF]  

I Wieselgren, P Lundborg, A Sandberg, B Olofsson, and R Bergstrand

Pharmacokinetic and pharmacodynamic evaluation of metoprolol controlled release (CR/ZOK) 50 mg in young subjects
J Clin Pharmacol 1990 30: S28 -S32. [Abstract] [PDF]  

B Oosterhuis, J Jonkman, P Zuiderwijk, and F Sollie

A pharmacokinetic and pharmacodynamic comparison of metoprolol CR/ZOK with a conventional slow release preparation
J Clin Pharmacol 1990 30: S33 -S38. [Abstract] [PDF]  

I Darmansjah, E Wong, A Setiawati, D Moeloek, D Irawati, M Siagian, and A Muchtar

Pharmacokinetic and pharmacodynamic properties of controlled release (CR/ZOK) metoprolol in healthy Oriental subjects: a comparison with conventional formulations of metoprolol and atenolol
J Clin Pharmacol 1990 30: S39 -S45. [Abstract] [PDF]  

B Abrahamsson, P Lucker, B Olofsson, CG Regardh, A Sandberg, I Wieselgren, and R Bergstrand

The relationship between metoprolol plasma concentration and beta 1-blockade in healthy subjects: a study on conventional metoprolol and metoprolol CR/ZOK formulations
J Clin Pharmacol 1990 30: S46 -S54. [Abstract] [PDF]  

M Kendall

Metoprolol CR/ZOK--its role and efficacy: a review article
J Clin Pharmacol 1990 30: S57 -S60. [PDF]  

G Carruthers, R Shearer, W Taylor, and M Moore

A comparison of a controlled release (CR/ZOK) formulation of metoprolol, once daily, with conventional metoprolol tablets, twice daily, in mild to moderate hypertension
J Clin Pharmacol 1990 30: S61 -S65. [Abstract] [PDF]  

A Jaattela, S Baandrup, J Houtzagers, and G Westergren

The efficacy of low dose metoprolol CR/ZOK in mild hypertension and in elderly patients with mild to moderate hypertension
J Clin Pharmacol 1990 30: S66 -S71. [Abstract] [PDF]  

G Klein, J Berger, G Olsson, and T Menzel

A double-blind comparison of metoprolol CR/ZOK 50 mg and atenolol 50 mg once daily for uncomplicated hypertension
J Clin Pharmacol 1990 30: S72 -S77. [Abstract] [PDF]  

G Leikersfeldt, SL Rasmussen, B Atmer, S Hjalmers, and I Wahlqvist

Efficacy and tolerability of a fixed combination of metoprolol CR/ZOK 100 mg and hydrochlorothiazide (HCT) 12.5 mg in comparison with the fixed combination of metoprolol and HCT
J Clin Pharmacol 1990 30: S78 -S81. [PDF]  

E Dimenas, J Ostergren, K Lindvall, C Dahlof, G Westergren, and U de Faire

Comparison of CNS-related subjective symptoms in hypertensive patients treated with either a new controlled release (CR/ZOK) formulation of metoprolol or atenolol
J Clin Pharmacol 1990 30: S82 -S90. [Abstract] [PDF]  

E Dimenas and C Dahlof

Tolerability and well-being with metoprolol in a controlled release (CR/ZOK) formulation: a review article
J Clin Pharmacol 1990 30: S92 -S97. [Abstract] [PDF]  

M Kendall, S Akhlaghi, B Hughes, and H Lewis

Is metoprolol CR/ZOK more selective than conventional metoprolol and atenolol?
J Clin Pharmacol 1990 30: S98 -S102. [Abstract] [PDF]  

E Dimenas, D Kerr, and I Macdonald

Beta-adrenoceptor blockade and CNS-related subjective symptoms: a randomized, double-blind, placebo-controlled comparison of metoprolol CR/ZOK, atenolol and propranolol LA in healthy subjects
J Clin Pharmacol 1990 30: S103 -S107. [Abstract] [PDF]  

J Patrick, J Bassey, J Morrant, and I Macdonald

Effects of a week's beta-adrenoceptor blockade with atenolol and metoprolol CR/ZOK on the response to exercise in healthy women aged 50 to 70 years
J Clin Pharmacol 1990 30: S108 -S116. [Abstract] [PDF]  

G Olsson, B Ablad, and L Ryden

Long-term cardiovascular effects of metoprolol therapy: a review article
J Clin Pharmacol 1990 30: S118 -S123. [Abstract] [PDF]  

T Linden, G Camejo, O Wiklund, I Warnold, SO Olofsson, and G Bondjers

Effect of short-term beta blockade on serum lipid levels and on the interaction of LDL with human arterial proteoglycans
J Clin Pharmacol 1990 30: S124 -S131. [Abstract] [PDF]  

AC Teger-Nilsson, C Dahlof, E Haglund, C Hedman, G Olsson, and B Ablad

Influence of metoprolol CR/ZOK on plasminogen activator inhibitor (PAI-1) in man: a pilot study
J Clin Pharmacol 1990 30: S132 -S137. [Abstract] [PDF]  

Biopharmaceutics/Pharmacokinetics/Hemodynamics:

Carl-Gunnar Regardh

Summary of Session I
J Clin Pharmacol 1990 30: S55 -S56. [PDF]  

Efficacy/Clinical:

Göran Berglund

Summary of Session II
J Clin Pharmacol 1990 30: S91 . [PDF]  

Quality of Life/Selectivity:

Johan Herlitz

Summary of Session III
J Clin Pharmacol 1990 30: S117 . [PDF]  

Mechamisms:

Gillis Johnsson

Summary of Session IV
J Clin Pharmacol 1990 30: S138 . [PDF]  

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