©© 2007 American College of Clinical Pharmacology, Inc.
The Journal of Clinical Pharmacology
, 10.1177/0091270006295788
Lung Deposition of Radiolabeled Tiotropium in Healthy Subjects and Patients With Chronic Obstructive Pulmonary Disease
Peter Brand 1*,
Thomas Meyer 1,
Thomas Weuthen 1,
Wolfgang Timmer 2,
Erhard Berkel 2,
Gudrun Wallenstein 2,
and
Gerhard Scheuch 3
1 Inamed Research GmbH & Co KG
2 Boehringer Ingelheim Pharma GmbH & Co KG
3 Activaero GmbH
* To whom correspondence should be addressed. E-mail: brand{at}inamed.de.
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Abstract |
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Lung deposition of 18 µg tiotropium administered via a dry-powder inhaler was investigated in 5 healthy subjects and patients with mild (n = 4), moderate (n = 6), and severe (n = 5) chronic obstructive pulmonary disease after 14 days of treatment with 18 µg tiotropium. On day 15, subjects inhaled 2 capsules of radiolabeled tiotropium, and lung deposition was assessed using 
scintigraphy. Repeated plasma and urine collections were performed on days 14 and 15. Mean delivered dose from the dry-powder inhaler was 45.1%. Mean lung deposition relative to the delivered dose was 42% (19%, relative to nominal dose) with low intersubject variability (20%). Mean extrathoracic deposition was 57.5% (25.8%, relative to nominal dose). There were no significant differences in deposition among the subgroups. No significant correlation between individual tiotropium deposition and lung function was observed. These results suggest that all stages of chronic obstructive pulmonary disease may gain full therapeutic benefit from the drug.
