J Clin Pharmacol
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The Journal of Clinical Pharmacology and the Journal of New Drugs, 1969; 9:163-174
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Comparison of Perphenazine and P-5227 in Chronic Schizophrenics: Clinical and EEG Effects

J. M. C. Holden M.D., M.R.C.P., D.P.M.1, T. M. Itil M.D.1, and A. Keskiner M.D.1

1 Department of Psychiatry at the Missouri Institute of Psychiatry, University of Missouri School of Medicine, 5400 Arsenal St., St. Louis, Mo.

The clinical, neurophysiologic, and laboratory effects of a new dibenzoxepine, P-5227, were compared with those of perphenazine. P-5227 was shown to have a greater antipsychotic effect than perphenazine. The importance of patient selection criteria and analysis of changes in a group of patients concurrently treated with placebo in all drug studies is emphasized. it is suggested that other compounds of similar structure be investigated.

Note:

We would like to thank Dr. Shapiro, D.Sc., for the statistical analysis and J. Townsend, R.N., and L. Wolin, R.N., for their assistance.


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Copyright © 1969 by the American College of Clinical Pharmacology