J Clin Pharmacol
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The Journal of Clinical Pharmacology and the Journal of New Drugs, 1969; 9:160-162
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Slow-Release Lithium Carbonate

Alec Coppen M.D., D.P.M.1, J. E. Bailey R.M.N.1, and S. G. White 1

1 Clinical Investigation Ward at Greenbank, West Park Hospital, Epsom, Surrey, England.

A slow-release form of lithium carbonate was tested on a group of eight patients after recovery from a depressive illness. It was found that after about one week an equilibrium was reached and that satisfactory plasma levels were sustained over 24 hours by a morning dose of slowrelease lithium carbonate. A dose of 1600 mg slow-release lithium carbonate gave satisfactory prophylactic levels in most cases although the final dose may need to be adjusted by following estimations of the plasma concentration of lithium in the individual patient.

Note:

We would like to thank Delandale Laboratories for the supply of the slow-release lithium carbonate, Priadel.


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Copyright © 1969 by the American College of Clinical Pharmacology