J Clin Pharmacol
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The Journal of Clinical Pharmacology and the Journal of New Drugs, 1969; 9:155-159
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Trimethoprim and Sulfalene Therapy of Plasmodium Vivax

Daniel C. Martin M.D.1 and John D. Arnold M.D.1

1 Harry S. Truman Laboratory, Department of Medicine, Kansas City General Hospital; The University of Missouri School of Medicine, Kansas City, Mo. 64108.

Forty-five volunteers infected with P. vivax malaria were treated with sulfonamides, a sulfone, and trimethoprim. Sulfalene, sulformethoxine, and diaminodiphenylsulfone were inadequate antimalarial agents when used alone. Trimethoprim was very effective, but required daily doses for five days to effect consistent cures (in seven of eight volunteers). The combination of sulfalene and trimethoprim was also very effective, requiring three doses for cure of bloodinduced P. vivax malaria.


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