J Clin Pharmacol
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The Journal of Clinical Pharmacology and the Journal of New Drugs, 1969; 9:99-103
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Further Studies on the Sites of Action Of Clopamide and Furosemide

Janos P. Rado M.D.1, Laszlo Szende M.D.1, Jozsef Tako M.D.1, Csaba Banos M.D.1, and Lajos Borbely M.D.1

1 Isotopie Department and Metabolic Unit and Department of Medicine, János Hospital, XIJ. Diòsàrok 4, Budapest, Hungary.

The effects of elopamide and furosemide as well as of their combination were studied in four subjects during angiotensin infusion in sustained maximal water diuresis. Both clopamide and furosemide administered alone reversed the decrease in free water clearance induced by angiotensin. On the other hand, in response to the combination of clopamide and furosemide a further decrease occurred in free water excretion during angiotensin infusion. The free water clearance studies suggested a proximal tubular site of action and an additive distal nephron effect for both clopamide and furosemide. This additive distal nephron effect may explain the increased effectiveness of the combination of drugs in overcoming the antidiuresis and antinatriuresis induced by angiotensin in comparison with the effectiveness of furosemide or clopamide administered alone.

Note:

We are greatly indebted to Prof. Dr. E. Flückiger (Basel) and Dr. Gehrmann (Frankfurt am Main) and to the firms Sandoz AG and Farbwerke Hoechst AG for the supplies of clopamide (DT 327, Brinaldix) and furosemide (Lasix). The valuable technical assistance of Mrs. Erzsébet Liptay, Mrs. Erzsébet Menyhárt, Miss Ilona Varga, and Mr. István Kapus is gratefully acknowledged.


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