J Clin Pharmacol
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The Journal of Clinical Pharmacology and the Journal of New Drugs, 1968; 8:172-179
test © 1968 the American College of Clinical Pharmacology
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Direct Measurement of the Anorectic Activity Of Diethylpropion (Tenuate Dospan)

J. Trevor Silverstone M.A., B.M., M.R.C.P., D.P.M.1, Paul Turner M.D., B.Sc., M.R.C.P.1, and P. L. Humpherson B.Sc., S.R.D.1

1 St. Bartholomew's Hospital, London, England.

The present investigations was undertaken to provide a quantitative estimate of the pharmacological effectiveness of long-acting diethylpropion (Tenuate Dospan) in reducing appetite and food intake and to determine its duration of action.

Following the administration of long acting diethylpropion, or identical-appearing placebo tablets at 10:00 A.M. to 18 overweight young women under strict double-blind conditions, hunger ratings were obtained on four occasions at specified intervals throughout the day until 10:00 P.M. In addition, estimates of calorie intake were made on the basis of three-hourly self-reporting of food consumption. An inquiry was also conducted into the effect of diethylpropion on rest lessness, dryness of the mouth, and sleep.

It was found that long-acting diethylpropion significantly reduced the level of subjective hunger during the day, but only on the first treatment day; and on this day there was also a significant reduction in food intake and an increase in dryness of the mouth. No significant differences were found between drug and placebo on the second treatment day. The significance of this is discussed in relation to similar findings in other investigations involving subjective judgments in be havioral tests.

It is concluded that long-acting diethylpropion has a definite appetitc suppressant action which may well form the basis of its known clinical efficacy in the treat ment of obesity.

Note:

We would like to express our gratitude to those members of the staff of the Dietetic Department of St. Bartholomew's Hospital who so diligently estimated the calorie intakes. We would also like to thank Dr. J. P. Birkett of Merrell-National Laboratories, Ltd., for his considerable assistance in the organization of this investigation.




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G. A. Bray and F. L. Greenway
Current and Potential Drugs for Treatment of Obesity
Endocr. Rev., December 1, 1999; 20(6): 805 - 875.
[Abstract] [Full Text]


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