Serum Concentrations after Rectal Administration of Lincomycin Hydrochloride

¹ Medical Research Division, The Upjohn Company.
² Sunland Hospital at Orlando, Orlando, Fla.
³ Borgess Hospital, Kalamazoo, Mich.

Results obtained in these studies indicate that absorption of lincomycin is greater when lincomycin hydrochloride is administered rectally as an aqueous solution than when it is administered rectally in suppository form. The aqueous solution of lincomycin hydrochloride given rectally appears to be nonirritating and does not promote defecation as was the case with the suppositories in some subjects. Based on serum concentrations, absorption of lincomycin from the solution given rectally averaged from about one half to approximately equal to the absorption attained following oral administration, the fraction being dependent upon the particular conditions employed in the study. Under usual condition of Use these data suggest that the dose of lincomycin administered rectally in the form of an aqueous solution must be about twice that given orally to provide equivalent serum concentrations of the antibiotic.

Note:

The microbiological assays performed by C. G. Chidester and H. M. Murray, The Up john Company, are gratefully acknowledged.

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