Evaluation of Acetaminophen-Salicylamide Combinations in Treatment of Headache

¹ Department of Surgery (Anesthesiology), University of North Carolina School of Medicine, Chapel Hill, N. C.

The effectiveness of acetaminophensalicylamide combinations in treatment of the common headache has been evaluated in a group of university students employing a blind Latin-square design. A total of 229 headaches were reported by 94 subjects during the fourweek study. The treatments and the per cent of treated headaches showing some degree of relief were: placebo: 46 per cent; aspirin, 648 mg: 78 per cent; acetaminophen, 487.5 mg plus salicylamide, 487.5 mg: 76 per cent; and acetaminophen, 325 mg plus salicylamide, 325 mg: 69 per cent. The percentages associated with all of the drug-containing regimens differed significantly from those of the placebo, but not from each other. Also, significantly fewer subjects who received drugs took additional analgesics than did subjects who received the placebo. Side effects were reported for the analgesics, but none were noted among those who took the placebo.

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