J Clin Pharmacol
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The Journal of New Drugs, 1965; 5:236-239
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Effect of Oral Enzyme Therapy on Roughage Content of Stools

Dale G. Friend M.D.1

1 Peter Bent Brigham hospital, Boston, Mass.; Harvard Medical School, Boston, Mass.

The feeding of ten ounces of corn to normal subjects is well tolerated and leads to the presence of considerable roughage in the bowel contents.

Tablets containing pepsin, N.F., 150 mg., pancreatic enzyme concentrate, 100 mg., cellulase, 25 mg., and dehydrocholic acid U.S.P., 50 mg., are well tolerated and reduce the roughage content of the bowel 30 to 50 per cent following the ingestion of corn.

This reduction in roughage may be of help in reducing gastrointestinal irritability in patients with the irritable bowel syndrome.


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