J Clin Pharmacol
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The Journal of New Drugs, 1965; 5:233-235
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Tybamate, a Meprobamate Analog, in the Treatment of Alcoholics

Horace B. Mooney M.D.1 and Keith S. Ditman M.D.1

1 Alcoholism Research Clinic, Neuropsychiatric Institute, University of California at Los Angeles, Calif.

Tybamate (Solacen), an analog of meprobamate, reportedly has an antagonistic effect on LSD-induced encephalographic changes in rabbits and a mildly stimulating effect on depressed patients. In a double-blind, controlled study with 102 outpatient alcoholics, tybamate (350 to 700 mg. four times daily) was not superior to meprobamate (400 to 800 mg. four times daily) or a placebo for the relief of symptoms common to alcoholics after one week of treatment. The large percentage of favorable placebo responders made demonstration of a superior treatment difficult.


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