J Clin Pharmacol
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The Journal of New Drugs, 1965; 5:225-232
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Evaluation of a New Sulfonamide, Sulfametin, In Urinary Tract Infections

Robert W. Chernoff M.D.1 and Sanford S. Klein M.D.2

1 University of Pennsylvania Department of Medicine, Philadelphia General Hospital, Philadelphia, Pa.
2 Philadelphia General Hospital, Philadelphia, Pa.

The antibacterial action of sulfametin (Sulla®) was evaluated initially in 77 patients with urinary tract infection. On the basis of the favorable clinical and bacteriological response in this open study, oral sulfametin, 250 and 500 mg. daily, was tested on a double-blind basis against sulfamethoxypyridazine, 500 mg. daily, and sulfadimethoxine, 500 mg. daily. All sulfa drugs were given for 14 days. In the double-blind study of 96 patients, sterile urines were achieved in six out of 24 patients who received sulfadimethoxine; in nine out of 24 patients who received sulfamethoxypyridazine; in 11 out of 24 patients who received 250 mg. sulfametin, and in 14 out of 24 patients who received 500 mg. sulfametin. Thus, it appears that the 500-mg. dosage strength of sulfametin was the most effective of the sulfa drugs tested.


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