Newer Methodology in the Clinical Investigation Of Anabolic Steroids

¹ Nutrition and Metabolic Research Division, The Burke Rehabilitation Center, White Plains, N. Y.; Geriatric Nutrition Laboratory, Miriam Osborn Memorial Home, Rye, N. Y.

Although the clinical usefulness of anabolic steroids has been amply defined by others, there remains the need to quantitate their metabolic effects under conditions of application. This is especially true of the newer synthetic steroids of low androgenic-high anabolic activity and of the corticosteroids.

In the present report the Steroid Protein Activity Index (SPAI) of nine orally administered anabolic steroids and six corticosteroids is reported. Additional studies done with parenteral anabolic steroids provide information on the relative SPAI and duration of activity of five of these preparations.

Trials with the oral administration of corticosteroids, followed by a period of combined corticosteroid and anabolic steroid therapy, permitted the determination of the Anticorticocatabolic Activity Index (ACAI). In this manner it was found that the positive action of the anabolic steroids on nitrogen retention could be quantitated and dosage relationships established, Some of the metabolic changes associated with the protein-anabolic and protein-catabolic effects of the test steroids were also measured and their significance discussed.

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