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The Journal of New Drugs, 1965; 5:121-124
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Effects of Chlordiazepoxide and Diazepam on the Influence of Meperidine on the Respiratory Response to Carbon Dioxide

Max S. Sadove M.D.1, R. C. Balagot M.D.1, and John M. McGrath M.D.2

1 University of Illinois Research and Education Hospitals, Chicago, Ill.
2 Northwestern University School of Medicine, Chicago, Ill.

Measurements of respiratory minute volume during a 5 per cent CO2 challenge in normal subjects revealed that neither chlordiazepoxide in doses of 100 mg. nor diazepam in 10 mg. doses significantly altered the respiratory response to meperidine. Differences between results with the test drugs and controls were statistically insignificant.


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