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PHARMACODYNAMICS

Inflammatory Mediators in Chinese Patients With Congestive Heart Failure

Yongqing Wang, PhD, Yanli Zhou, MD, PhD, Ling Meng, MD, Xinzheng Lu, MD, PhD, Ning Ou, MD and Xinli Li, MD, PhD

From First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

In this study, circulating levels of proinflammatory and anti-inflammatory mediators are studied in patients with chronic heart failure (CHF) in China. Sixty-five patients with CHF and 32 control subjects are studied. The proinflammatory and anti-inflammatory cytokines interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-{alpha}, atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) in plasma are determined by immunoradiometric assay kits. Catecholamine (CA) in plasma is evaluated by high-performance liquid chromatography. Plasma levels of IL-6, IL-10, TNF-{alpha}, ANP, BNP, and CA in CHF patients are significantly higher than those in control subjects. Patients in a higher New York Heart Association (NYHA) class show higher concentrations of inflammatory mediators than those in a lower NYHA class, although the ratio of plasma IL-10 to TNF-{alpha} in patients with CHF is significantly lower than in the control group. It is concluded that proinflammatory and anti-inflammatory cytokine levels are increased and IL-10/TNF-{alpha} is decreased in Chinese patients with CHF.

Key Words: Heart failure • TNF-{alpha} • interleukin-10 • interleukin-6 • BNP

Address for reprints: Prof. Xinli Li, MD, PhD, Cardiology Department, The first affiliated hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029; e-mail: xinli3267{at}yeah.net, fax: 86-25-83673396 and Yongqing Wang, PhD, Research Division of Clinical Pharmacology, The first affiliated hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029; e-mail: wangyq999{at}yahoo.com.cn.


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