HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Sign In to gain access to subscriptions and/or personal tools.

This Article Full Text Full Text (PDF) All Versions of this Article: 0091270007312155v1 48/3/344    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Request Reprints Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Re, R. N. Articles by Cook, J. L. Search for Related Content PubMed PubMed Citation Articles by Re, R. N. Articles by Cook, J. L.

The Basis of an Intracrine Pharmacology

From the Ochsner Clinic Foundation, New Orleans, Louisiana.

Intracrines are extracellular signaling peptide factors that can act in the intracellular space after either internalization or retention in the cells that synthesize them. They are structurally diverse and include hormones, growth factors, enzymes, DNA-binding proteins, and other peptide moieties. We have suggested principles of intracrine action and have applied those principles to forms of cellular and tissue differentiation, hormonal responsiveness, and memory. Moreover, recent findings make clear that some currently available pharmaceuticals act via the alteration of intracrine function. Thus, the beginnings of an intracrine pharmacology are at hand and we here review principles applicable to the design of such agents. The intracrine pharmacology of the renin-angiotensin system, angiogenesis, and stem cell development is discussed.

Key Words: Intracrine • angiotensin • angiogenesis • differentiation

Address for correspondence: R N Re, MD, Scientific Director, Ochsner Clinic Foundation, New Orleans, LA 70121; e-mail: rre{at}ochsner.org.

This article has been cited by other articles:

				R. N. Re and J. L. Cook The physiological basis of intracrine stem cell regulation Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H447 - H453. [Abstract] [Full Text] [PDF]