HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 0091270007311571v1 48/3/279    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Request Reprints Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Phillips, M. Articles by Ward, S. Search for Related Content PubMed PubMed Citation Articles by Phillips, M. Articles by Ward, S. Social Bookmarking                   What's this?

Pharmacokinetics of Glucarpidase in Subjects With Normal and Impaired Renal Function

From Protherics Medicines Development Ltd, The Heath Business & Technical Park, Runcorn, Cheshire, UK (Dr Phillips); New Orleans Center for Clinical Research, New Orleans, LA (Dr Smith); Procter & Gamble Pharmaceuticals, Mason, OH (Dr Balan); and Protherics Inc, Brentwood, TN (Dr Ward).

Glucarpidase (formerly known as carboxypeptidase G2 or CPG2) is being evaluated for the adjunctive treatment of patients experiencing, or at risk of, methotrexate toxicity attributable to its delayed elimination. Delayed elimination of methotrexate can occur in patients with methotrexate-induced renal toxicity. In this study, glucarpidase pharmacokinetics were assessed in volunteer subjects with normal (n = 8) and severely impaired (n = 4) renal function. Each subject received a single intravenous dose of glucarpidase 50 U/kg (equivalent to 114.5 µg/kg) infused over 5 minutes. The mean maximum serum concentration (C_max) for glucarpidase in renally impaired subjects was 2.9 µg/mL, the mean half-life (t) was 10.0 hours, and the mean area under the serum concentration-time curve from time zero to infinity (AUC_0-) was 24.5 µgxh/mL. Similar values were found in subjects with normal renal function (mean C_max 3.1 µg/mL, mean t 9.0 hours, and mean AUC_0- 23.4 µgxh/mL). The results indicated little effect of renal impairment on the serum pharmacokinetics of glucarpidase.

Key Words: Glucarpidase • methotrexate • renal • Voraxaze

Address for correspondence: Marc Phillips, PhD, Protherics PLC, The Heath Business & Technical Park, Runcorn, Cheshire, WA7 4QX, UK.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?