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THERAPEUTIC REVIEW

Pharmacologic Consideration for the Use of Antiretroviral Agents in the Elderly

Martin S. Rhee, MD and David J. Greenblatt, MD

From Tufts Medical Center, Department of Medicine, Division of Geographic Medicine and Infectious Diseases, Boston, Massachusetts (Dr Rhee), and Tufts University School of Medicine, Department of Pharmacology and Experimental Therapeutics, Boston, Massachusetts (Dr Greenblatt). Dr Daniel Sitar acted as Editor for this paper.

The prevalence of human immunodeficiency virus (HIV) infection among people older than 50 years is increasing. HIV-infected patients require lifelong treatment with antiretroviral agents to suppress viral replication and maintain immune function. The use of antiretroviral agents in the elderly can be complicated by multiple chronic comorbidities and coadministered non-HIV medications. The pharmacokinetics of antiretroviral agents may be altered due to age-related decrements in hepatic and renal function. The elderly may be more sensitive than younger people to antiretroviral drug toxicity. A better understanding of the pharmacokinetics of antiretroviral agents in the elderly is of importance for the successful management of complex antiretroviral regimens in this population.

Key Words: HIV • antiretroviral • pharmacokinetics • elderly

Address for reprints: Martin S. Rhee, MD, Tufts Medical Center, 800 Washington Street, Box 41, Boston, MA 02111; e-mail: mrhee{at}tufts-nemc.org.


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