J Clin Pharmacol
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DRUG DELIVERY

Smart Textiles: A New Drug Delivery System for Symptomatic Treatment of a Common Cold

F. Wienforth, MD, A. Landrock, C. Schindler, MD, J. Siegert, MD, PharmD and W. Kirch, MD, PhD

From the Institute of Clinical Pharmacology, Medical Faculty, Technical University Dresden, Dresden, Germany. Dr Schindler is a member of the American College of Clinical Pharmacology. Dr Kirch is a fellow of the American College of Clinical Pharmacology.

Smart textiles provide the possibility of being coated with cineole, menthol, and camphor. Due to over-the-counter availability, ethereal oils are frequently used to treat a common cold. The existing pharmaceutical forms entail the risk of oral ingestion by children, which can cause severe intoxications. This risk could be limited by a smart textile application. Prior to applicability tests in children, the principal traceability of smart textile-applied ethereal oils at their site of action in the alveoli has to be demonstrated. Therefore, a crossover trial (ointment vs smart textiles) with 6 healthy volunteers was carried out as a proof-of-concept study. As a result, the principle proof is given that smart textile-applied ethereal oils are available at their site of action. Because of the volatility of the active ingredients, a close-fitting textile form has to be developed for further clinical development of smart textiles to achieve higher concentrations in the alveoli. Slower liberation properties and a more convenient skin sensation in comparison to available pharmaceutical forms may provide advantages for the applicability in both children and adults.

Key Words: Dermal application • textiles • cineole • camphor • menthol

Address for reprints: Address for correspondence: Florian Wienforth, MD, Institute of Clinical Pharmacology, Medical Faculty, Technical University Dresden, Fiedlerstr. 27, 01307 Dresden, Germany; e-mail: florian.wienforth{at}tu-dresden.de.






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