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Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids

From the Pharmacy, Hôpital Hautepierre, Strasbourg, France, and the Institute of Bacteriology, Strasbourg, France.

This review focuses on the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of Catharanthus (vinca) alkaloids pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.

Key Words: Catharanthus alkaloids • vinblastine • vincristine • vindesine • vinorelbine • CYP450 • drug transporters • orphan nuclear receptors • drug-drug interactions

Address for reprints: Address for correspondence: Dominique Levêque, Pharmacy-Pharmacology, Hôpital Hautepierre, Avenue Molière, 67000 Strasbourg, France; e-mail: dominique.leveque{at}chru-strasbourg.fr.