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Short-Term Clinical Exposure Evaluation of a Second-Generation Electrically Heated Cigarette Smoking System

From Philip Morris USA, Richmond, Virginia.

This randomized, controlled, forced-switching, open-label, parallel-group study in 100 adult male and female smokers of conventional cigarettes evaluated 8 biomarkers of tobacco smoke exposure. After baseline exposure determinations, adult smokers were switched to a second-generation electrically heated cigarette smoking system (EHCSS) for 8 days in a clinical setting. After 8 days of smoking the EHCSS biomarkers of exposure decreased by 43% to 85% compared to baseline. After correction for residual effects (carryover effects due to long elimination half-life and non-tobacco-confounding sources of exposure), reductions in exposure ranged from 59% to 97%. Results from this short-term clinical exposure study indicate that switching from a conventional cigarette to a second-generation electrically heated cigarette smoking system substantially reduced the exposure to several measured potentially harmful constituents of tobacco smoke.

Key Words: Biomarkers • exposure evaluation • controlled smoking

Address for reprints: Hans J. Roethig, Philip Morris USA, Research Center, 4102 Commerce Road, Richmond, VA 23234; e-mail: Hans-Juergen.Roethig{at}pmusa.com.

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