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Pharmacokinetics of Desmopressin Administrated as an Oral Lyophilisate Dosage Form in Children With Primary Nocturnal Enuresis and Healthy Adults

From Ferring Pharmaceuticals A/S, Kay Fiskers Plads 11 DK-2300 Copenhagen S, Denmark (Dr Østerberg, Dr Nørgaard, Dr Agersø); Department of Pharmaceutical Biosciences, Uppsala University, Sweden (Mr Savic, Dr Karlsson, Dr Simonsson); Department of Pediatric Nephrology, UZ Gent, Belgium (Dr Walle).

The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag-time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic difference was minor and presumably of no clinical relevance.

Key Words: Desmopressin • pharmacokinetics • primary nocturnal enuresis • modeling • transit absorption model

Address for reprints: Ole Østerberg, Ferring Pharmaceuticals A/S, Kay Fiskers Plads 11 DK-2300 Copenhagen S, Denmark.

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