J Clin Pharmacol
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THERAPEUTIC REVIEWS

Clinical Trials in Amyotrophic Lateral Sclerosis: The Tenuous Past and the Promising Future

Rabia B. Choudry, MD and Merit E. Cudkowicz, MD, MSc

From the Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston.

The past decade of research in amyotrophic lateral sclerosis has contributed to a greater understanding of the disease process, the development of relevant animal models, and the identification of several therapeutic approaches that may delay disease progression. Completed and ongoing clinical trials and the process of selecting drugs for clinical trials are presented.

Key Words: Amyotrophic lateral sclerosis • clinical trials • drug trials

Address for reprints: Rabia B. Choudry, MD, Massachusetts General Hospital, 55 Fruit Street, GRB 1256, Boston, MA 02114; e-mail: rchoudry{at}partners.org.


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