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Drug Utilization in the Pediatric Intensive Care Unit: Monitoring Prescribing Trends and Establishing Prioritization of Pharmacotherapeutic Evaluation of Critically Ill Children

From the Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia (Dr Zuppa, Dr Adamson, Mr Mondick, Mr Narayan, Mr Nicholson, Ms Patel, Ms Collison, Dr Barrett); the Department of Anesthesia and Critical Care, Division of Critical Care, The Children's Hospital of Philadelphia (Dr Zuppa, Ms Davis); and the Department of Pharmacy Services, The Children's Hospital of Philadelphia (Dr Maka).

The primary objective of this study was to characterize the drug exposure for children hospitalized in the authors' institution's pediatric intensive care unit for the year 2002. Secondary objectives included the examination of drug utilization differences among various age criteria and the suitability of the most prevalent resources for pediatric dosing guidance. Many of the most commonly prescribed agents in the pediatric intensive care unit fall into the broad categories of pain management/sedation and anti-infectives. Based on the generally narrow windows afforded by each of these drug classes, it is obvious that more, well-defined investigations in critically ill children are warranted. The existing dosing guidance for many of these agents is neither generalizable nor sufficient to accommodate the diversity in pediatric intensive care unit patients, and the current drug monographs fall short of any practical dosing information.

Key Words: Drug utililzation • pediatric intensive care • prescribing practices • pharmacoepidemiology

Address for reprints: Athena F. Zuppa, Division of Clinical Pharmacology and Therapeutics, Abramson Research Center Suite 916J, The Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104.

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This article has been cited by other articles:

				A. Zuppa, S. Vijayakumar, B. Jayaraman, D. Patel, M. Narayan, K. Vijayakumar, J. T. Mondick, and J. S. Barrett An Informatics Approach to Assess Pediatric Pharmacotherapy: Design and Implementation of a Hospital Drug Utilization System J. Clin. Pharmacol., September 1, 2007; 47(9): 1172 - 1180. [Abstract] [Full Text] [PDF]