HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Sign In to gain access to subscriptions and/or personal tools.

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Request Reprints Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by VanDenBerg, C. M. Articles by Azzaro, A. J. Search for Related Content PubMed PubMed Citation Articles by VanDenBerg, C. M. Articles by Azzaro, A. J. Social Bookmarking                         What's this?

Tyramine Pharmacokinetics and Reduced Bioavailability with Food

From Somerset Pharmaceuticals, Inc., Tampa, Florida (Dr. VanDenBerg, Ms. Kemper, Dr. Azzaro) and Potomac Clinical Trials, Jessup, Maryland (Dr. Blob).

Tyramine challenge studies have demonstrated that it requires approximately twice the amount of tyramine administered with a meal compared to administration after a fast to elicit the same effect, suggesting a reduction in bioavailability of tyramine when administered with food. The pharmacokinetics of tyramine when administered in a fasted versus a fed state were studied. A single 200-mg dose of tyramine was administered orally to healthy subjects both after an overnight fast and during a meal. Systemic exposure to tyramine was reduced by 53% (p< 0.05), and the maximum concentration of tyramine was reduced by 72% (p< 0.05) when the dose was administered during a meal. Tyramine maximum serum concentration was observed between 20 minutes and 1 hour when the dose was administered after an overnight fast and appeared to be delayed and/or prolonged by administration during a meal. Tyramine oral clearance was 135 ± 55.4 L/min, maximum observed serum concentration was 37.7 ± 26.01 ng/mL, and tyramine elimination half-life was 0.533 (range: 0.330-0.668) hours after administration to fasted subjects. Tyramine bioavailability was significantly reduced when administered with a meal compared to after a fast. The results suggest that larger amounts of dietary tyramine will be required to induce a pressor response equivalent to that following encapsulated tyramine administered in the fasted state.

Key Words: Tyramine • pharmacokinetics • bioavailability

Address for reprints: Chad VanDenBerg, PharmD, 2202 N. West Shore Blvd. Ste. #450, Tampa, FL 33607.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. J. Azzaro, C. M. VanDenBerg, L. F. Blob, E. M. Kemper, M. Sharoky, D. A. Oren, and B. J. Campbell Tyramine Pressor Sensitivity During Treatment With the Selegiline Transdermal System 6 mg/24 h in Healthy Subjects. J. Clin. Pharmacol., August 1, 2006; 46(8): 933 - 944. [Abstract] [Full Text] [PDF]