J Clin Pharmacol
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The Journal of New Drugs, 1964; 4:46-51
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Cyproheptadine in the Treatment of Alcoholics

Horace B. Mooney M.D.1, Keith S. Ditman M.D.1, and Sidney Cohen M.D.1

1 Alcoholism Research Clinic, Department of Psychiatry, U. C. L. A. Center for the Health Sciences, Los Angeles 24, Calif.

Cyproheptadine in doses of 16 and 40 mg. daily or matching placebos were given to 130 outpatient alcoholics in a double-blind study. The return rate for further treatment was considerably lower for those patients who were given the drug. Only 31 of the 66 patients (47 per cent) started on cyproheptadine kept weekly appointments after the first week of treatment, compared to 39 of the 64 patients (61 per cent) given placebo. Unpleasant but not serious side effects were frequently reported, especially daytime drowsiness and sleepiness. Except for the evidence of sedation there were no apparent psychotropic effects on these patients.


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Copyright © 1964 by the American College of Clinical Pharmacology