J Clin Pharmacol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jung, D.
Right arrow Articles by Hulse, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jung, D.
Right arrow Articles by Hulse, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Steady-State Relative Bioavailability of Three Oral Ganciclovir Dosage Regimens Delivering 6,000 mg/day in Patients with Human Immunodeficiency Virus

Donald Jung, PhD

Kay Griffy, PharmD

Rodney Wong, PhD

Roche Global Development, Palo Alto, California

Wayne Colburn, PhD, FCP

Harris Laboratories, Inc., Phoenix, Arizona

Jim Hulse, PhD

Lincoln, Nebraska

This study was designed to determine the steady-state relative bioavailability of ganciclovir after three dosage regimens designed to deliver 6,000 mg/day. The study design was an open-label, randomized, three-treatment crossover design in which 22 human immunodeficiency virus (HIV) and cytomegalovirus (CMV) seropositive ptients received in random order multiple oral doses of ganciclovir 1,000 mg six times a day, 1,500 mg four times a day, and 2,000 mg three times a day. Blood samples were obtained on day 3 of each oral regimen over a 24-hour time interval. Mean steady-state average serum concentrations of ganciclovir were greater than 1.0 1tg/mL, which exceeds the median in vitro inhibitory concentration (1%)) of most CMV isolates (0.5-1.0 FLg/mL). All three regimens resulted in values for area under the concentration-time curve from 0 to 24 hours (AUCO 24) that were comparable to those seen after maintenance ganciclovir intravenous infusions of 5 mg/kg/day. The 1,000 mg six times daily regimen resulted in an AUCO,24 that was significantly higher than that of the 1,500 mgfour times daily or the 2,000 mg three times daily regimens, although the differences were less than 12.5%.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American College of Clinical Pharmacology