J Clin Pharmacol
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Acebutolol overdose treated with hemodialysis and extracorporeal membrane oxygenation

M Rooney, KL Massey, F Jamali, M Rosin, D Thomson, and DH Johnson

A case involving a 27-year-old woman who ingested an overdose of acebutolol is presented. Extracorporeal membrane oxygenation was initiated to stabilize the patient's condition before commencing hemodialysis. S-diacetolol (the N-acetelation product of acebutolol) was cleared with hemodialysis. It is suggested that extracorporeal membrane oxygenation may be of short-term benefit in the treatment of overdoses with beta-adrenergic agents such as acebutolol when accelerated clearance with hemodialysis is anticipated.
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