| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Sign In to gain access to subscriptions and/or personal tools.
|
|
|
|||||||
Sign In to gain access to subscriptions and/or personal tools. |
|||||||||
Articles |
The pharmacodynamics of three corticosteroids were investigated after intravenous administration of the phosphate esters of methylprednisolone, dexamethasone, and triamcinolone acetonide to healthy subjects at 20, 50, and 80 mg as well as placebo. Twenty-two different pharmacodynamic parameters were followed as a function of time for 48 hours. Statistically significant effects of the glucocorticoids were an increase in blood glucose levels, a decrease in the number of lymphocytes, eosinophils, basophils, and monocytes, and an increase in the number of granulocytes and stab cells. For the most significant pharmacodynamic effects (lymphocytes, granulocytes, and glucose) a previously derived integrated pharmacokinetic/pharmacodynamic model using plasma concentrations, protein-binding data, and in vitro receptor-binding affinities was used to predict the pharmacodynamic effect-time profiles. Good agreement of predicted and measured effects was observed, confirming the validity of the model. The clinical significance of the model was demonstrated by comparison of model-predicted maintenance doses with empirically determined clinical equivalency doses.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. D. Lowe, T. K. Graves, K. L. Campbell, and D. J. Schaeffer A Pilot Study Comparing the Diabetogenic Effects of Dexamethasone and Prednisolone in Cats J. Am. Anim. Hosp. Assoc., September 1, 2009; 45(5): 215 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Drescher, H. Li, A. Lundgaard, C. Bunger, and E.-S. Hansen Endothelin-1-Induced Femoral Head Epiphyseal Artery Constriction Is Enhanced by Long-Term Corticosteroid Treatment J. Bone Joint Surg. Am., November 1, 2006; 88(suppl_3): 173 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Hochhaus New Developments in Corticosteroids Proceedings of the ATS, November 1, 2004; 1(3): 269 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Mager, S. X. Lin, R. A. Blum, C. D. Lates, and W. J. Jusko Dose Equivalency Evaluation of Major Corticosteroids: Pharmacokinetics and Cell Trafficking and Cortisol Dynamics J. Clin. Pharmacol., November 1, 2003; 43(11): 1216 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ward, J. Watson, P. Wood, C. Dunne, and D. Kerr Glucocorticoid epidural for sciatica: metabolic and endocrine sequelae Rheumatology, January 1, 2002; 41(1): 68 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Kingery, G. S. Agashe, S. Sawamura, M. F. Davies, J. D. Clark, and M. Maze Glucocorticoid Inhibition of Neuropathic Hyperalgesia and Spinal Fos Expression Anesth. Analg., February 1, 2001; 92(2): 476 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Brus Effects of High-Dose Inhaled Corticosteroids on Plasma Cortisol Concentrations in Healthy Adults Arch Intern Med, September 13, 1999; 159(16): 1903 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Georgitis The 1997 Asthma Management Guidelines and Therapeutic Issues Relating to the Treatment of Asthma Chest, January 1, 1999; 115(1): 210 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H Steer, D. T S Ma, L. Dusci, G. Garas, K. E Pedersen, and D. A Joyce Altered leucocyte trafficking and suppressed tumour necrosis factor alpha release from peripheral blood monocytes after intra-articular glucocorticoid treatment Ann Rheum Dis, December 1, 1998; 57(12): 732 - 737. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Kaufman Treatment of multiple sclerosis with high-dose corticosteroids may prolong the prothrombin time to dangerous levels in patients taking warfarin Multiple Sclerosis, August 1, 1997; 3(4): 248 - 249. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
